NCT07119970Recruiting
Prognostic Value of NETosis Markers for Thrombosis During Myeloproliferative Neoplasms (AVATARE)
Prospective Study for the Evaluation of the Prognostic Value of NETosis Markers to Predict Thrombosis in Myeloproliferative Neoplasms With JAK2V617F Mutation (AVATARE)
Source: ClinicalTrials.gov · Last updated 13 Jan 2026
Brief summary (registry, in English)
Myeloproliferative neoplasms are hematologic diseases characterized by an increased proliferation of peripheral blood cells. The main risk of MPN is the occurrence of thrombosis. Thrombosis risk is mainly evaluated using two criteria: age and prior thrombosis. A better prediction of thrombosis risk is needed to improve prevention and treatment of MPN-associated thrombosis. The objective of the study is to evaluate the predictive value of neutrophil extracellular traps markers in thrombosis during MPN.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 1 Jul 2025
- Start date
- 9 Dec 2025
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- University Hospital, Bordeaux
- Diseases
- Myeloproliferative neoplasms
- NCT number
- NCT07119970
What you commit to
- Study type: Interventional
- Planned participants: 300
- From 9 Dec 2025 to the primary completion date, 31 Dec 2028
- 15 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Severe hepatic or renal insufficiency (Creatinine clearance \<30ml/min)
Other
- Patients under legal protection (guardianship or curatorship)
- Patients under heparin treatment at inclusion
Who the study is looking for
- Diagnosis of Polycythemia Vera (PV), Essential Thrombocythemia (ET), or pre-myelofibrosis (pre-MF)
- JAK2V617F mutation with an allelic burden greater than 1%
- High risk of thrombosis (age over 60 years or prior thrombotic event)
- Diagnosis of MPN within the last 12 months
- Enrollment in the AVAJAK clinical trial and the FIMBANK biobank
- Affiliation with social security
- Signed informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (15)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU d'Angers - Service des Maladies du sang Coordinator of this site? Confirm its status | Angers | France | Not yet recruiting |
| CH DE LA COTE BASQUE - Service Hématologie Coordinator of this site? Confirm its status | Bayonne | France | Not yet recruiting |
| CHU de Bordeaux, service Hématologie Biologique Coordinator of this site? Confirm its status | Bordeaux | France | Not yet recruiting |
| CHU de Bordeaux, service Hématologie Clinique et Thérapie cellulaire Coordinator of this site? Confirm its status | Bordeaux | France | Not yet recruiting |
| CHU de Brest, Service Hématologie et Hémostase Clinique Coordinator of this site? Confirm its status | Brest | France | Not yet recruiting |
| APHP-Hôpital Mondor, Service Hématologie Clinique et Thérapie Cellulaire Coordinator of this site? Confirm its status | Créteil | France | Not yet recruiting |
| CHD de Vendée, Service Onco-hématologie Coordinator of this site? Confirm its status | La Roche-sur-Yon | France | Not yet recruiting |
| APHP-Hôpital Bicêtre, Service Hématologie Clinique Ambulatoire Coordinator of this site? Confirm its status | Le Kremlin-Bicêtre | France | Not yet recruiting |
| CH de Libourne, Service Hématologie Coordinator of this site? Confirm its status | Libourne | France | Recruiting |
| CHU de Limoges, Service Hématologie Clinique et de Thérapie Cellulaire Coordinator of this site? Confirm its status | Limoges | France | Not yet recruiting |
| CH des Pays de Morlaix, Service Onco-Hématologie Coordinator of this site? Confirm its status | Morlaix | France | Not yet recruiting |
| CHU de Nantes, Service Hématologie Clinique Coordinator of this site? Confirm its status | Nantes | France | Not yet recruiting |
| Hôpital Privé du Confluent, Service Hématologie Coordinator of this site? Confirm its status | Nantes | France | Not yet recruiting |
| APHO-Hôpital Saint-Louis, Centre d'Investigations Cliniques Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| CH de Roubaix, Service Hématologie Coordinator of this site? Confirm its status | Roubaix | France | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.