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NCT07119970Recruiting

Prognostic Value of NETosis Markers for Thrombosis During Myeloproliferative Neoplasms (AVATARE)

Prospective Study for the Evaluation of the Prognostic Value of NETosis Markers to Predict Thrombosis in Myeloproliferative Neoplasms With JAK2V617F Mutation (AVATARE)

Source: ClinicalTrials.gov · Last updated 13 Jan 2026

Brief summary (registry, in English)

Myeloproliferative neoplasms are hematologic diseases characterized by an increased proliferation of peripheral blood cells. The main risk of MPN is the occurrence of thrombosis. Thrombosis risk is mainly evaluated using two criteria: age and prior thrombosis. A better prediction of thrombosis risk is needed to improve prevention and treatment of MPN-associated thrombosis. The objective of the study is to evaluate the predictive value of neutrophil extracellular traps markers in thrombosis during MPN.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
300 (estimated)
First submitted
1 Jul 2025
Start date
9 Dec 2025
Primary completion date
31 Dec 2028
Lead sponsor
University Hospital, Bordeaux
NCT number
NCT07119970

What you commit to

  • Study type: Interventional
  • Planned participants: 300
  • From 9 Dec 2025 to the primary completion date, 31 Dec 2028
  • 15 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Lab values

  • Severe hepatic or renal insufficiency (Creatinine clearance \<30ml/min)

Other

  • Patients under legal protection (guardianship or curatorship)
  • Patients under heparin treatment at inclusion

Who the study is looking for

  • Diagnosis of Polycythemia Vera (PV), Essential Thrombocythemia (ET), or pre-myelofibrosis (pre-MF)
  • JAK2V617F mutation with an allelic burden greater than 1%
  • High risk of thrombosis (age over 60 years or prior thrombotic event)
  • Diagnosis of MPN within the last 12 months
  • Enrollment in the AVAJAK clinical trial and the FIMBANK biobank
  • Affiliation with social security
  • Signed informed consent

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (15)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
CHU d'Angers - Service des Maladies du sang
Coordinator of this site? Confirm its status
AngersFranceNot yet recruiting
CH DE LA COTE BASQUE - Service Hématologie
Coordinator of this site? Confirm its status
BayonneFranceNot yet recruiting
CHU de Bordeaux, service Hématologie Biologique
Coordinator of this site? Confirm its status
BordeauxFranceNot yet recruiting
CHU de Bordeaux, service Hématologie Clinique et Thérapie cellulaire
Coordinator of this site? Confirm its status
BordeauxFranceNot yet recruiting
CHU de Brest, Service Hématologie et Hémostase Clinique
Coordinator of this site? Confirm its status
BrestFranceNot yet recruiting
APHP-Hôpital Mondor, Service Hématologie Clinique et Thérapie Cellulaire
Coordinator of this site? Confirm its status
CréteilFranceNot yet recruiting
CHD de Vendée, Service Onco-hématologie
Coordinator of this site? Confirm its status
La Roche-sur-YonFranceNot yet recruiting
APHP-Hôpital Bicêtre, Service Hématologie Clinique Ambulatoire
Coordinator of this site? Confirm its status
Le Kremlin-BicêtreFranceNot yet recruiting
CH de Libourne, Service Hématologie
Coordinator of this site? Confirm its status
LibourneFranceRecruiting
CHU de Limoges, Service Hématologie Clinique et de Thérapie Cellulaire
Coordinator of this site? Confirm its status
LimogesFranceNot yet recruiting
CH des Pays de Morlaix, Service Onco-Hématologie
Coordinator of this site? Confirm its status
MorlaixFranceNot yet recruiting
CHU de Nantes, Service Hématologie Clinique
Coordinator of this site? Confirm its status
NantesFranceNot yet recruiting
Hôpital Privé du Confluent, Service Hématologie
Coordinator of this site? Confirm its status
NantesFranceNot yet recruiting
APHO-Hôpital Saint-Louis, Centre d'Investigations Cliniques
Coordinator of this site? Confirm its status
ParisFranceNot yet recruiting
CH de Roubaix, Service Hématologie
Coordinator of this site? Confirm its status
RoubaixFranceNot yet recruiting

This page is information, not medical advice. Discuss any trial with your doctor.