NCT07120867Completed
Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical Trial
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to find out if performing a pleural fluid drainage (thoracentesis) together with the measurement of pressure inside the chest (pleural manometry) during the same procedure can help doctors choose the best treatment for each patient with malignant pleural effusion.The main questions it aims to answer are: * Is the use of pleural manometry associated with a higher success rate in managing malignant pleural effusion through pleurodesis? * Can the use of pleural manometry help guide optimal therapeutic decision-making in malignant pleural effusion? Researchers will compare the success of the chosen treatment in patients who undergo pleural manometry to those who do not, to see if pleural manometry helps improve treatment outcomes for malignant pleural effusion. Participants will: * Receive treatment according to the hospital's standard clinical practice for managing malignant pleural effusion. * If assigned to the manometry group, they will undergo pleural manometry during their first thoracentesis. * If the manometry results suggest that the lung can fully expand, they will be referred for pleurodesis-just as patients in the non-manometry group are. * If the manometry results suggest that the lung cannot fully expand, pleurodesis will not be recommended due to the high risk of failure. Instead, placement of a tunneled pleural catheter will be advised to help control symptoms.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 55 (actual)
- First submitted
- 30 Jul 2025
- Start date
- 28 Jul 2023
- Primary completion date
- 20 Feb 2026
- Lead sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- NCT number
- NCT07120867
What you commit to
- Study type: Interventional
- Participants enrolled: 55
- From 28 Jul 2023 to the primary completion date, 20 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous ipsilateral lobectomy or pneumonectomy
- Previous ipsilateral chemotherapy or radiotherapy
Other illness
- Presence of infected pleural effusion
Other
- Radiological evidence of non-expandable lung
- Life expectancy \<1 month (LENT score: high risk)
- Patient preference for tunneled pleural catheter placement
- Pregnancy
- Thrombocytopenia or coagulopathy
- Contraindication to general anesthesia or sedation
Who the study is looking for
- Histologically confirmed cancer and symptomatic patient with at least one of the following:
- Malignant pleural effusion confirmed by cytology.
- Recurrent exudative pleural effusion without an alternative diagnosis in the context of confirmed extrapleural cancer.
- Pleural effusion associated with hypermetabolic pleural thickening suggestive of malignant pleural effusion.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.