NCT07121582Recruiting
Modulation of Brain Rhythms in Stroke
Modulation of Beta Oscillatory Rhythms in Stroke to Promote Corticomuscular Circuit Function
Source: ClinicalTrials.gov · Last updated 27 Apr 2026
Brief summary (registry, in English)
The goal of this research study is to examine communication between brain and muscle in individuals with stroke and determine if applying non-invasive brain stimulation to different parts of the brain improves this communication and performance on a hand squeezing task. The investigators will fit participants with an electroencephalography (EEG) cap and place electromyography (EMG) stickers on participants hand and arm muscles to record brain and muscle activity, respectively. Participants will complete a single research visit lasting approximately 3 hours. During this visit, participants will receive two different types of non-invasive brain stimulation: \[1\] stimulation to the motor part of the brain and \[2\] stimulation to the visual part of the brain. Participants will be randomized so that half will receive stimulation to the motor part of the brain first followed by stimulation to the visual part of the brain second and vice versa. Participants will complete three blocks of hand squeezing trials using the stroke-affected (weak) hand. During the first block of squeezing trials, no brain stimulation will occur. During the second and third blocks, participants will receive stimulation just before each hand squeezing trial. The investigators will record participants' brain and muscle activity during these blocks of hand squeezing trials. Additionally, participants will also complete screening tests and exams looking at mood, motor function, and cognition.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 6 Aug 2025
- Start date
- 1 Dec 2025
- Primary completion date
- Jan 2027
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Stroke
- NCT number
- NCT07121582
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 1 Dec 2025 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent physical/occupational therapy and/or clinical trial participation related to stroke
Other illness
- Contraindications to TMS (seizure activity within past 2 years, pregnancy, indwelling metal)
- Injury or conditions that impact affected extremity-use beyond stroke (e.g., arthritis)
- Cerebellar stroke
- Major medical/neurological/psychiatric condition impacting physical function in the opinion of the physician co-investigator
Other
- Cognitive deficits (Montreal Cognitive Assessment \< 21 points)
- Impaired vision despite use of aid (e.g. glasses, contacts, etc.)
- Absent ipsilesional motor-evoked potential response
Who the study is looking for
- Chronic (≥ 6 months) unilateral cortical/subcortical ischemic or hemorrhagic stroke as confirmed by medical records
- Upper extremity weakness (hemiparesis) contralateral to the stroke
- Sufficient cognitive capacity (Montreal Cognitive Assessment ≥ 21 points), communication function, and English proficiency to understand and safely comply with all study procedures
- Ipsilesional motor-evoked potential response
- Able to perform isometric grip task by making a fist with their stroke-affected hand (hand contralateral to the stroke)
Age in the registry: 45 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bondurant Hall Coordinator of this site? Confirm its status | Chapel Hill | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.