NCT07123337Completed
Serum 25-Hydroxyvitamin D and Neurological Disability in Multiple Sclerosis
Serum 25-Hydroxyvitamin D and Neurological Disability in Multiple Sclerosis: A Cross-Sectional Study From the Mediterranean Epidemiological Frontier
Source: ClinicalTrials.gov · Last updated 19 Aug 2025
Brief summary (registry, in English)
Vitamin D is hypothesized to play a role in the immunopathology and progression of multiple sclerosis (MS), yet its association with neurological disability remains uncertain, particularly in North African populations.We conducted a cross-sectional study involving 369 adult MS patients across two tertiary neurology centers in Western Libya. Serum 25-hydroxyvitamin D \[25(OH)D\] levels and Expanded Disability Status Scale (EDSS) scores were collected. Pearson correlation, ANOVA, and multivariable linear regression were used to assess associations between vitamin D and disability, adjusting for age, BMI, disease duration, and physical activity. Missing data and outliers were handled systematically using validated R and Python workflows.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 369 (actual)
- First submitted
- 7 Aug 2025
- Start date
- 1 Aug 2023
- Primary completion date
- 15 Feb 2025
- Lead sponsor
- University of Zintan
- Diseases
- Multiple sclerosis
- NCT number
- NCT07123337
What you commit to
- Study type: Observational
- Participants enrolled: 369
- From 1 Aug 2023 to the primary completion date, 15 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- presence of other neurological disorders that could mimic MS (e.g., neuromyelitis optica spectrum disorder or Lyme disease).
- extreme psychiatric or cognitive impairment.
Other
- missing or incomplete medical records.
- pregnancy or lactation.
Who the study is looking for
- Libyan nationals.
- aged 18 years or older.
- diagnosis of MS based on the 2017 revised McDonald criteria.
- capable of providing informed consent.
- had complete clinical, demographic, and biochemical data.
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of medicine zintan university Coordinator of this site? Confirm its status | Tripoli | Libya | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.