Comparing Postoperative Adjuvant Cisplatin Concurrent Chemoradiotherapy With Adjuvant Radiotherapy Alone for Intermediate-risk Head and Neck Squamous Cell Carcinoma

Prior treatment

• Previous chemotherapy (except induction chemotherapy prior to surgery).
• Previous radiation therapy.

Other illness

• Previous history of malignant tumor.
• With other serious medical conditions that may pose a greater risk or affect compliance with the test. Examples include:
• unstable heart disease that requires treatment
• kidney disease
• chronic hepatitis
• mental illness.

Lab values

• poorly controlled diabetes (fasting blood glucose \> 1.5×ULN)

Age

• Age \>70 years or \<18 years.

Other

• Treatment is palliative.
• Women who are pregnant or breastfeeding

• The pathological type is head and neck squamous cell carcinoma
• Stages
• Radical surgery has been performed, and there are intermediary-risk factors (pT3/pT4, pN2/pN3, positive lymph nodes in the cervical IV/V region of oral cancer, nerve invasion, and vascular invasion).
• No evidence of distant metastasis (M0).
• Functional status: Karnofsky scale (KPS) \> 70.
• Normal bone marrow function:
• white blood cell count \> 4×109/L
• hemoglobin \> 120g/L in males, 110g/L in females
• platelet count \> 100×109/L
• Normal liver function:
• alanine aminotransferase (ALT), aspartate aminotransferase (AST) \< 1.5 times the upper limit of normal (ULN)
• alkaline phosphatase (ALP) \< 2.5×ULN
• bilirubin \< ULN.
• Normal renal function: creatinine clearance \> 60 ml/min.
• Patients must be informed of the basic contents of this study and sign informed consent.