NCT07126743Active, not recruiting
Organic Pollutant Build-Up in Body Fat and Stomach Tissue Linked to Obesity Levels
Accumulation Profiles of Specific Organic Pollutants in Adipose and Gastric Tissues of Bariatric Surgery Patients and Their Clinical Correlations With Obesity Severity
Source: ClinicalTrials.gov · Last updated 17 Aug 2025
Brief summary (registry, in English)
This study looks at whether certain environmental chemicals, called organic pollutants, build up in the body fat and stomach tissues of people with obesity who are having weight-loss (bariatric) surgery. These pollutants can come from things like plastics, pesticides, or industrial waste, and may affect health in different ways. The investigators will measure the amount of these pollutants in tissue samples taken during surgery and see if the levels are different in people with mild, moderate, or severe obesity. By understanding these patterns, the investigators hope to learn more about how environmental factors may influence obesity and related health problems. The findings could help guide future prevention and treatment strategies for patients.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 11 Aug 2025
- Start date
- Aug 2025
- Primary completion date
- Aug 2026
- Lead sponsor
- Dong Peng
- Diseases
- Obesity
- NCT number
- NCT07126743
What you commit to
- Study type: Observational
- Planned participants: 100
- From Aug 2025 to the primary completion date, Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior bariatric or major upper gastrointestinal surgery that alters stomach/anatomy relevant to sampling.
- Pregnant or breastfeeding at screening or on day of surgery.
- Inadequate tissue obtainable at surgery for analysis (determined intraoperatively by the investigators).
Other illness
- Active malignancy (excluding non-melanoma skin cancers) or ongoing systemic immunosuppressive therapy (e.g., chronic corticosteroids, biologics) within 3 months.
- Acute infection or decompensated chronic illness that would preclude elective surgery per treating team.
Lab values
- Severe organ dysfunction: decompensated cirrhosis (Child-Pugh C) or eGFR \<30 mL/min/1.73m².
Other
- Documented high-level occupational or accidental chemical exposure within 6 months (e.g., pesticide poisoning) likely to bias tissue pollutant measurements.
- Participation in another interventional study expected to affect weight or metabolism within 3 months.
Who the study is looking for
- Adults ≥18 years.
- BMI ≥30 kg/m² at screening (measured within 30 days before surgery).
- Scheduled for primary bariatric surgery (e.g., sleeve gastrectomy or Roux-en-Y gastric bypass) for clinical indications.
- Able to provide informed consent.
- Willing to allow intraoperative collection of subcutaneous/visceral adipose tissue and gastric tissue for pollutant analysis.
- Availability of basic preoperative clinical data (demographics, comorbidities, relevant labs).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.