NCT07131631Recruiting
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER. The target sample will be up to 125 patients enrolled to achieve 100 evaluable at 6 months of follow-up. Enrollment will occur at up to eight centers.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 125 (estimated)
- First submitted
- 6 Aug 2025
- Start date
- 3 Mar 2022
- Primary completion date
- Jul 2027
- Lead sponsor
- Minneapolis Heart Institute Foundation
- Diseases
- Heart failure
- NCT number
- NCT07131631
What you commit to
- Study type: Observational
- Planned participants: 125
- From 3 Mar 2022 to the primary completion date, Jul 2027
- 6 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant PCI and TEER
- Prior mitral valve repair or replacement
Other illness
- Congenital heart disease
- Stage D heart failure
Other
- Uncontrolled atrial fibrillation
- Pregnancy
- \> moderate tricuspid regurgitation
- \>moderate aortic regurgitation or stenosis
- Contraindications or unable to undergo CMR
Who the study is looking for
- 1\. Adult patients (≥ 18 years old) with heart failure and reduced ejection fraction (LVEF \< 50% defined by echocardiography), medically and device-optimized according to guidelines, with significant FMR undergoing TEER with FDA-approved MitraClip device (Abbott Structural, USA)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Ospedale San Raffaele Coordinator of this site? Confirm its status | Milan | Italy | Enrolling by invitation |
| Sanger Heart and Vascular Institute Coordinator of this site? Confirm its status | Charlotte | United States | Enrolling by invitation |
| The Christ Hospital Health Network Coordinator of this site? Confirm its status | Cincinnati | United States | Enrolling by invitation |
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Enrolling by invitation |
| Inova Fairfax Medical Campus Coordinator of this site? Confirm its status | Falls Church | United States | Enrolling by invitation |
| Minneapolis Heart Institute Foundation Coordinator of this site? Confirm its status | Minneapolis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.