NCT07133256Completed
Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease
Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 21 Aug 2025
Brief summary (registry, in English)
This randomized controlled trial investigates the comparative effects of aerobic versus resistance training on bone mineral density (BMD) and bone metabolism markers in patients with stage 3 or 4 chronic kidney disease (CKD). The primary aim is to evaluate the impact of two distinct exercise modalities on serum osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL), and the OPG/RANKL ratio, as well as densitometric changes at key skeletal sites.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 6 Aug 2025
- Start date
- 1 Jan 2025
- Primary completion date
- 1 Jul 2025
- Lead sponsor
- Sinai University
- Diseases
- Chronic kidney disease
- NCT number
- NCT07133256
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 1 Jan 2025 to the primary completion date, 1 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of investigational drugs or enrollment in another clinical trial during the study period
Other illness
- Diagnosis of type 1 diabetes mellitus
- Uncontrolled hypertension
- History of cardiovascular, musculoskeletal, endocrine, or metabolic bone disease
Other
- Pregnant or planning pregnancy during the study period
- Participation in a structured exercise program within the last 3 months
- Contraindications to exercise as determined by medical evaluation
Who the study is looking for
- Adults aged 30 to 50 years
- Diagnosed with stage 3 or 4 chronic kidney disease (non-dialysis dependent)
- BMI between 20 and 24 kg/m²
- Not currently taking medications that affect bone density (e.g., corticosteroids, bisphosphonates)
- Non-smokers and abstinent from alcohol
- Not receiving hormone replacement therapy
- Willing and able to participate in supervised exercise sessions for 6 months
Age in the registry: 30 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Manshyet El-Bakry Hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.