NCT07135856Recruiting
Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC
Comparative Analysis of Minimally Invasive and Open Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC: A Multicenter Retrospective Evaluation of Surgical Outcomes
Source: ClinicalTrials.gov · Last updated 31 Dec 2025
Brief summary (registry, in English)
The goal of this observational, retrospective, multicenter cohort study is to evaluate the surgical and oncologic outcomes of sleeve lobectomy performed via minimally invasive (RATS/VATS) or open thoracotomy approaches in patients with non-small cell lung cancer (NSCLC) who have undergone neoadjuvant therapy, including chemotherapy, immunotherapy, or combination regimens. The main questions this study aims to answer are: * Does minimally invasive sleeve lobectomy result in comparable or improved perioperative and postoperative outcomes compared to open thoracotomy following neoadjuvant treatment in NSCLC? * Does surgical approach influence oncologic endpoints such as margin status, lymph node dissection, recurrence-free survival, and overall survival? This research addresses a critical gap in the thoracic oncology field by evaluating the safety, complexity, and efficacy of advanced surgical techniques in the context of evolving multimodal therapy paradigm. Findings may inform clinical decision-making and optimize patient selection in an era of increasing use of neoadjuvant strategies for resectable NSCLC.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 8 Aug 2025
- Start date
- 1 Sept 2025
- Primary completion date
- 1 Nov 2025
- Lead sponsor
- Shanghai Chest Hospital
- Diseases
- Lung cancer
- NCT number
- NCT07135856
What you commit to
- Study type: Observational
- Planned participants: 400
- From 1 Sept 2025 to the primary completion date, 1 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Absence of neoadjuvant therapy
- Purely diagnostic surgical procedures
Other illness
- Metastatic (stage IV) disease at time of surgery
Other
- Sublobar resections (e.g., segmentectomy) or pneumonectomy
- Incomplete medical records or lost to follow-up
Who the study is looking for
- Age ≥ 18 years
- Histologically confirmed NSCLC
- Undergoing sleeve lobectomy with curative intent
- Receipt of neoadjuvant therapy (chemotherapy, immunotherapy, target therapy, etc.)
- Surgical approach: either minimally invasive (VATS or RATS) or open thoracotomy
- Availability of complete perioperative and follow-up data (minimum 12-month follow-up or until death)
- Signed informative consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Chest Hospital Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.