Primary Radiotherapy In MEtastatic Lung Cancer

Prior treatment

• Medically unfit for systemic therapy
• Has had previous thoracic radiotherapy of \> 36Gy within the 6 months prior to randomisation.
• Has been diagnosed and/or treated additional malignancy within 2 years prior to randomisation with the exception of: Curatively treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, curatively treated early-stage cervical cancer, breast cancer or prostate cancer with no evidence of active disease and not on active therapy. Other exceptions may be considered following consultation with the principal investigator
• Uncontrolled brain metastasis not amenable to debulking surgery or stereotactic radiotherapy

Other illness

• Has a history of (non-infectious) pneumonitis or current pneumonitis that requires active corticosteroids with a dose equivalent of prednisolone \> 10mg/d.
• A known diagnosis of fibrotic interstitial lung disease
• Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
• Has an active autoimmune disease that has required systemic treatment within last year (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment and is allowed

Lab values

• EGFR/ALK/ROS1 mutation positive or actionable driver mutation with intention to use available targeted drug therapy

• Newly diagnosed metastatic (stage IV) NSCLC, not amenable to curative surgery or curative radiotherapy
• Histologically or cytologically documented NSCLC
• Primary suitable for radiotherapy and not requiring immediate palliative thoracic irradiation
• Investigator deemed appropriate for SoC systemic therapy
• Metastases in up to 3 organ systems