NCT07138040Recruiting
Re-Engaging AYA Survivors in Cancer-Related Healthcare
Re-Engaging AYA Survivors in Cancer-Related Healthcare: A Sequential Multiple Assignment Randomized Trial
Source: ClinicalTrials.gov · Last updated 18 Feb 2026
Brief summary (registry, in English)
The goal of this clinical trial is to test the efficacy (how well they work) of different digital interventions that deliver information to adolescent and young adult (AYA) survivors of childhood cancer to promote re-engagement in cancer-related long-term follow-up care (LTFU). The main aims are: * To test the efficacy of adaptive interventions (AIs) that begin with low touch intervention (LTI) as compared to written information (WI) on attending an appointment, and self-reported self-management among AYA. * To identify the most efficacious second-stage strategy for those who initially schedule/attend an appointment (maintenance vs. step-up) and for those who do not (step-up vs. step-up maximum). * To assess multilevel factors contributing to the effects of re-engaging AYA and how best to integrate AIs into practice. Throughout the duration of the study, participants will complete four surveys, receive a series of interventions, and may be asked to participate in an interview (post-intervention).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 530 (estimated)
- First submitted
- 15 Aug 2025
- Start date
- 1 Aug 2025
- Primary completion date
- 30 Apr 2028
- Lead sponsor
- Children's Hospital of Philadelphia
- Diseases
- Childhood cancers
- NCT number
- NCT07138040
What you commit to
- Study type: Interventional
- Planned participants: 530
- From 1 Aug 2025 to the primary completion date, 30 Apr 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received surgery only treatment
Other illness
- Cognitive impairment limiting participation
- Currently living with cancer diagnosis (either new, metastatic, recurrence, or relapse)
Other
- Transferred to primary care
- Absence of documentation of treatment history
- Absence of inclusion criteria above
- No involvement in the AYA's healthcare
- AYA Decline support person's participation
- Absence of inclusion criteria above
Who the study is looking for
- 15-29 years old
- History of a childhood cancer diagnosis, diagnosed prior to age 22
- Has not had a cancer-related follow-up visit in at least 15 months (or is 3 months past recommended follow-up)
- U.S. resident (not international patient)
- Has previously attended a cancer-related appointment at Children's Hospital of Philadelphia, or Nationwide Children's Hospital or Penn
- At least 2 years from end of treatment and 5 years from diagnosis
- English proficient
- For AYA under age 18, must have a caregiver to provide informed consent
- Primary caregiver or other support person (e.g. partner, sibling, other caregiver)
- At least 18 years old
- U.S. resident
- English proficient
Age in the registry: 15 years to 29 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nationwide Children's Hospital Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Penn Medicine Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Children's Hospital of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.