NCT07138690Completed
Complications and Failure of Centrally Inserted Central Catheters in Cardiac Surgical Patients
A Retrospective, Single-center Observational Study on Ultrasound-guided Centrally Inserted Central Catheters Catheter-related Bloodstream Infection and Catheters Failure in Adult Cardiac Surgical Patients.
Source: ClinicalTrials.gov · Last updated 3 Sept 2025
Brief summary (registry, in English)
Central venous catheters, or CVCs, are medical devices used to deliver medications and blood products directly into a patient's large veins. They are now an essential part of modern hospital care, but their use comes with potential complications. Two of the most serious and well-studied complications are catheter-related bloodstream infections and catheter-related thrombosis (blood clots). These issues not only pose significant health risks to patients but also increase healthcare costs. Fortunately, the frequency of these complications has been reduced by following universally accepted prevention measures, such as: Proper hand hygiene and skin disinfection before insertion Using an ultrasound to guide the procedure Applying best practices for ongoing catheter maintenance Besides infections and blood clots, other complications like accidental displacement, lumen occlusion (blockage), or a suspected infection can lead to the early, or premature, removal of a CVC before the completion of the patient's treatment. In patients undergoing cardiac surgery, CVCs are vital. They are used for general anesthesia, medication delivery, and continuous monitoring of a patient's heart and circulatory system. Because of this critical role, it's essential to constantly monitor the incidence of CVC-related complications in this patient population. This single-center, retrospective study will investigate two primary objectives: The frequency of catheter-related infections in adult patients undergoing cardiac surgery. The frequency of premature catheter removals, or "catheter failures," in the same patient group. The findings from this study will help improve the management of CVCs in cardiac surgery patients and reduce and prevent future complications.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 480 (actual)
- First submitted
- 13 Aug 2025
- Start date
- 1 Jun 2022
- Primary completion date
- 31 Dec 2023
- Lead sponsor
- Azienda Ospedaliero-Universitaria Careggi
- NCT number
- NCT07138690
What you commit to
- Study type: Observational
- Participants enrolled: 480
- From 1 Jun 2022 to the primary completion date, 31 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who died within 7 days of surgery.
- Patients with a CICC already in place at the time of surgery.
Other illness
- Patients with infection confirmed by another source.
- Cardiac anesthesiologist with less than 2 years of cardiac surgery experience and/or fewer than 100 procedures per year.
Age
- Patients under 18 years of age.
Other
- Patients with active endocarditis.
- Patients with preoperative sepsis.
- Patients with a CICC placed in the left IJV, subclavian veins, or femoral veins.
Who the study is looking for
- Patients aged \>18 years.
- Signed informed consent for contactable patients and those who will be attending the treatment center for follow-up visits.
- Patients undergoing elective or emergency cardiac surgery during the study period.
- Cardiac anesthesiologist performing the procedure with \>2 years of experience in cardiac surgery and with \>100 ultrasound-guided CICC placement procedures per year.
- Patient with a triple- or quad-lumen CICC placed in the right internal jugular vein.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cardiac ICU - Department of Anesthesia and Intensive Care - Careggi University Hospital Coordinator of this site? Confirm its status | Florence | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.