NCT07141862Recruiting
Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method
Fertility Preservation in Children With Neuroblastoma or Ewing's Sarcoma: Detection of Residual Disease by a Sensitive Method
Source: ClinicalTrials.gov · Last updated 3 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
In prepubertal patients, cryopreservation of ovarian or testicular tissue is currently the only available method for fertility preservation prior to gonadotoxic cancer treatments. However, this approach carries the risk of reintroducing malignant cells upon autotransplantation, particularly in cases of metastatic cancers such as neuroblastoma and Ewing sarcoma. Therefore, it is crucial to employ highly sensitive techniques to detect minimal residual disease (MRD) in preserved gonadal tissues. This study aims to identify the most effective detection method by comparing the sensitivity and specificity of reverse transcription quantitative PCR (RT-qPCR) and droplet digital PCR (ddPCR) in identifying MRD of neuroblastoma and Ewing sarcoma in ovarian and testicular tissues from patients treated for these malignancies during infancy.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 89 (estimated)
- First submitted
- 19 Aug 2025
- Start date
- 1 Feb 2025
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- University Hospital, Clermont-Ferrand
- Diseases
- Neuroblastoma, Childhood cancers, Sarcoma
- NCT number
- NCT07141862
What you commit to
- Study type: Observational
- Planned participants: 89
- From 1 Feb 2025 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- None
Who the study is looking for
- Women of any age diagnosed with a benign cyst requiring laparoscopy may be included.
- Men of any age diagnosed with a non-obstructive azoospermia may be included.
- Prepubertal girls and boys diagnosed with neuroblastoma or Ewing sarcoma during infancy may be included.
- Capable of providing written informed consent to participate in the research study
- Affiliated with a social welfare service.
- For prepubertal patients, written informed consent to participate in the research study must be provided by their parents or legal guardians.
Age in the registry: 2 years to 45 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University hospital Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.