Fact CheckerSign in

NCT07141901Not yet recruiting

Life Expectancy-informed Colorectal Cancer Screening

Improving Colorectal Cancer Screening Decisions Through Consideration of Life Expectancy

Source: ClinicalTrials.gov · Last updated 20 Oct 2026

Brief summary (registry, in English)

The purpose of this study is to improve life-expectancy concordant colorectal cancer screening for adults over 75 years through design and testing of a life expectancy notification to clinicians delivered via the electronic health record. This study has three components: 1. The investigators will develop a life expectancy prediction model using patient data from the Cleveland Clinic electronic health record (EHR) and test it against two existing life expectancy prediction models to determine which should be used in clinical care. This is an observational cohort study. 2. Concurrently with the development and testing of the life expectancy prediction model, the investigators will conduct interviews with clinicians to generate knowledge regarding the optimal way to integrate life expectancy information into decision making about colorectal cancer screening in patients over 75 years. This is a qualitative study. 3. The investigators will then conduct a cluster randomized trial of a clinical decision support-delivered life expectancy notification on life expectancy-congruent colorectal cancer screening orders by primary care clinicians.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
15000 (estimated)
First submitted
19 Aug 2025
Start date
1 Mar 2027
Primary completion date
1 Sept 2028
Lead sponsor
Kathryn Martinez
NCT number
NCT07141901

What you commit to

  • Study type: Interventional
  • Planned participants: 15000
  • From 1 Mar 2027 to the primary completion date, 1 Sept 2028
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Patients being actively treated for non-skin cancer
    • Aim 1b:
  • Patients up to date with colorectal cancer screening (colonoscopy within 10 years or FOBT/FIT/Cologuard within the past year)

Age

  • Patients aged ≤75 years
  • Clinicians who are not in the top or bottom quarter of the distribution of colonoscopy orderers for patients aged \>75 years
  • Patients aged \<75 years

Other

  • All candidates meeting any of the exclusion criteria at baseline will be excluded from study participation.
    • Aim 1a:
  • Patients who did not have at least one subsequent Internal or Family Medicine visit in Ohio within two years from the date of their baseline visit
  • Trainees/residents
  • Saw \<10 study-eligible patients between 2024-2025
    • Aim 2:

Who the study is looking for

  • Aim 1a: Patients must meet all the inclusion criteria listed below to be included:
    • \> 75 years of age
    • Resident of Ohio
    • Had at least one Internal Medicine or Family Medicine visit at Cleveland Clinic Health System between January 1, 2007, and September 1, 2022.
    • Aim 1b: Clinicians must meet all the inclusion criteria listed below to be included:
  • Internal Medicine or Family Medicine clinician (MD, DO, or APP) practicing at Cleveland Clinic Health System in Northeast Ohio
  • Saw ≥10 study-eligible patients, defined as patients aged \>75 years who were due or overdue for colorectal cancer screening, between 2024-2025
  • With a colonoscopy ordering rate for patients \>75 years in either the top quarter of the distribution of all eligible clinicians or bottom quarter of all eligible clinicians
    • Aim 2: Clinics must meet all the inclusion criteria listed below to be included:
  • Internal Medicine or Family Medicine clinical site included in the Cleveland Clinic Health System in Northeast Ohio or Florida
    • Clinicians must meet all the inclusion criteria listed below to be included:
  • Currently practicing in Internal or Family Medicine as an attending clinician
  • Saw ≥10 study-eligible patients, defined as patients aged \>75 years who were due or overdue for colorectal cancer screening, between 2024-2025
    • Patients must meet all the inclusion criteria listed below to be included:
  • \>75 years of age
  • Have not received a colonoscopy in the prior 10 years
  • Have not received a FOBT/FIT in prior year
  • Had a visit in Internal Medicine or Family Medicine between January 1, 2026 and January 1, 2028

Age in the registry: 76 years to - · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Cleveland Clinic
Coordinator of this site? Confirm its status		ClevelandUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.