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NCT07143461Completed

Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without Migraine

The Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Patients With Migraine and Control: a Randomized Clinical Trial

Source: ClinicalTrials.gov · Last updated 3 Sept 2026

Brief summary (registry, in English)

This study comprised two separate assessor-blinded randomized crossover experiments, one in participants with migraine and one in participants without migraine. Within each cohort, participants completed two experimental conditions on separate study visits: 10 minutes of self-selected personal prayer and 10 minutes of non-spiritual reading. The order of the two conditions was randomized within each cohort. The primary outcome was cephalic pressure pain threshold (PPT), assessed immediately before and after each experimental condition at eight craniofacial sites. The study examined acute changes in PPT following prayer and reading. Spiritual well-being, religiosity, anxiety symptoms, and depressive symptoms were assessed once at baseline to characterize the participants and were not repeated following the experimental conditions. A total of 109 participants were enrolled: 57 participants with migraine and 52 participants without migraine.

Status (registry)
Completed
Study type
Interventional
Enrollment
109 (actual)
First submitted
1 Jul 2025
Start date
29 Sept 2023
Primary completion date
29 Sept 2025
Lead sponsor
University of Sao Paulo
Diseases
Migraine
NCT number
NCT07143461

What you commit to

  • Study type: Interventional
  • Participants enrolled: 109
  • From 29 Sept 2023 to the primary completion date, 29 Sept 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Severe acute circulatory disorders
  • Decompensated diabetes mellitus

Other

  • Cognitive weaknesses that prevent the patient from understanding and carrying out the study procedures.

Who the study is looking for

  • Diagnosis of chronic or episodic migraine.
  • Feeling comfortable performing a known prayer.

Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Institute of Psychiatry of the University of São Paulo
Coordinator of this site? Confirm its status
São PauloBrazilUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.