NCT07145190Recruiting
SL-START - SubLingual Apomorphine Schemes of TitrAtion in Real-world Treatment
SL-APO in the Treatment of Patients With Parkinson's Disease: a Real-world Evidence Study to Identify Titration and Usage Schemes - SL-START
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
The purpose of the study is to generate real-world evidence data for the on-demand treatment with SL-APO, focusing on understanding its usage and titration practices including individual dose determination after dose-adjustment to ultimately understand their influence in patient satisfaction, treatment persistence, and the balance between effectiveness and safety. The data may help optimize titration approaches to better meet the patient's needs.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 90 (estimated)
- First submitted
- 21 Aug 2025
- Start date
- 27 Aug 2025
- Primary completion date
- Feb 2028
- Lead sponsor
- Bial - Portela C S.A.
- Diseases
- Parkinson disease
- NCT number
- NCT07145190
What you commit to
- Study type: Observational
- Planned participants: 90
- From 27 Aug 2025 to the primary completion date, Feb 2028
- 12 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- The patient is participating in a clinical trial with an investigational drug.
Other illness
- The patient has presented with dementia or evidence of cognitive decline as determined by the investigator.
- The patient has a history of psychotic disorder.
Other
- The patient presents any other contraindication according to the SL-APO SmPC.
Who the study is looking for
- The patient is ≥ 18 years of age.
- The patient has a clinical diagnosis of idiopathic Parkinson's disease.
- The patient will initiate SL-APO for the treatment of OFF episodes according to the SmPC.
- The patient is not currently on titration or maintenance dose for SL-APO.
- The patient has provided written informed consent to participate in this study.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (12)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Praxis für Neurologie Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Charité - Universitätsmedizin Berlin - Sektion für Bewegungsstörungen und Neuromodulation Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Alexianer St. Joseph Berlin-Weißensee GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Suspended |
| Katholisches Klinikum Bochum gGmbH, Universitätsklinikum St.Josef-Hospital, Klinik für Neurologie Coordinator of this site? Confirm its status | Bochum | Germany | Not yet recruiting |
| UNIVERSITÄTSKLINIKUM FREIBURG - Neurozentrum Klinik für Neurologie und Neurophysiologie im Neurozentrum Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Recruiting |
| Praxis für Neurologie und Psychiatrie Coordinator of this site? Confirm its status | Fulda | Germany | Recruiting |
| Klinik am Tharandter Wald Coordinator of this site? Confirm its status | Hetzdorf | Germany | Recruiting |
| Klinik für Neurologie und Neurologische Frührehabilitation Coordinator of this site? Confirm its status | Osnabrück | Germany | Recruiting |
| Die Nerven Docs Coordinator of this site? Confirm its status | Siegen | Germany | Recruiting |
| Neurologische Klinik Sorpesee Coordinator of this site? Confirm its status | Sundern | Germany | Recruiting |
| Praxis für Neurologie und Geriatrie Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
| Neurologie am Funkerberg Coordinator of this site? Confirm its status | Wusterhausen | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.