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NCT07145190Recruiting

SL-START - SubLingual Apomorphine Schemes of TitrAtion in Real-world Treatment

SL-APO in the Treatment of Patients With Parkinson's Disease: a Real-world Evidence Study to Identify Titration and Usage Schemes - SL-START

Source: ClinicalTrials.gov · Last updated 11 Aug 2026

Brief summary (registry, in English)

The purpose of the study is to generate real-world evidence data for the on-demand treatment with SL-APO, focusing on understanding its usage and titration practices including individual dose determination after dose-adjustment to ultimately understand their influence in patient satisfaction, treatment persistence, and the balance between effectiveness and safety. The data may help optimize titration approaches to better meet the patient's needs.

Status (registry)
Recruiting
Study type
Observational
Enrollment
90 (estimated)
First submitted
21 Aug 2025
Start date
27 Aug 2025
Primary completion date
Feb 2028
Lead sponsor
Bial - Portela C S.A.
NCT number
NCT07145190

What you commit to

  • Study type: Observational
  • Planned participants: 90
  • From 27 Aug 2025 to the primary completion date, Feb 2028
  • 12 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • The patient is participating in a clinical trial with an investigational drug.

Other illness

  • The patient has presented with dementia or evidence of cognitive decline as determined by the investigator.
  • The patient has a history of psychotic disorder.

Other

  • The patient presents any other contraindication according to the SL-APO SmPC.

Who the study is looking for

  • The patient is ≥ 18 years of age.
  • The patient has a clinical diagnosis of idiopathic Parkinson's disease.
  • The patient will initiate SL-APO for the treatment of OFF episodes according to the SmPC.
  • The patient is not currently on titration or maintenance dose for SL-APO.
  • The patient has provided written informed consent to participate in this study.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (12)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Praxis für Neurologie
Coordinator of this site? Confirm its status
BerlinGermanyRecruiting
Charité - Universitätsmedizin Berlin - Sektion für Bewegungsstörungen und Neuromodulation
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BerlinGermanyRecruiting
Alexianer St. Joseph Berlin-Weißensee GmbH
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BerlinGermanySuspended
Katholisches Klinikum Bochum gGmbH, Universitätsklinikum St.Josef-Hospital, Klinik für Neurologie
Coordinator of this site? Confirm its status
BochumGermanyNot yet recruiting
UNIVERSITÄTSKLINIKUM FREIBURG - Neurozentrum Klinik für Neurologie und Neurophysiologie im Neurozentrum
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Freiburg im BreisgauGermanyRecruiting
Praxis für Neurologie und Psychiatrie
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FuldaGermanyRecruiting
Klinik am Tharandter Wald
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HetzdorfGermanyRecruiting
Klinik für Neurologie und Neurologische Frührehabilitation
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OsnabrückGermanyRecruiting
Die Nerven Docs
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SiegenGermanyRecruiting
Neurologische Klinik Sorpesee
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SundernGermanyRecruiting
Praxis für Neurologie und Geriatrie
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UlmGermanyRecruiting
Neurologie am Funkerberg
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WusterhausenGermanyRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.