NCT07146412Active, not recruiting
Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
Source: ClinicalTrials.gov · Last updated 29 Sept 2026
Brief summary (registry, in English)
Many individuals develop dementia, and dementia has multiple causes, yet we currently have limited treatment options. A critical observation of the effectiveness of the available dementia treatments is that they tend to be more effective when started early. Previous studies have shown that multimodal lifestyle interventions can significantly delay the onset of Alzheimer's dementia in individuals with high risk for Alzheimer's or with Mild Cognitive Impairment (MCI). These interventions may be less effective when initiated after dementia has already been diagnosed or is more advanced. This study has two primary goals. The first goal is to assess attitudes around dementia risk for participants throughout the study as they learn of their personalized risk and possible lifestyle factors that may modify that risk. The second goal is to serve as a logistical pilot for the implementation of data collection and processing and multimodal lifestyle intervention to reduce the risk factors of dementia in individuals without current cognitive impairment but who are at high risk of progression to dementia. Secondary goals of this study include better defining what factors contribute the most risk to dementia and identifying sub-types of dementia defined by different genetic and molecular risk factors.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 15 Aug 2025
- Start date
- 2 May 2025
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- HudsonAlpha Institute for Biotechnology
- Diseases
- Alzheimer disease
- NCT number
- NCT07146412
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 2 May 2025 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- A diagnosis of cognitive impairment of any kind, including Alzheimer's disease, mild cognitive impairment, or any other diagnosis of dementia
- If a subject is found to have cognitive impairment at initial enrollment (Montreal Cognitive Assessment (MoCA) score\<25), they will be excluded from the study
- Self-reported chronic or end-stage disease that would interfere with their participation in the study
- Severe hearing and visual impairment that would interfere with the ability to complete study measures
Age
- Children under 19 years of age
Other
- Self-reported pregnancy
- Individuals not fluent in written and spoken English
- Hospitalization for any reason in the past 3 months
- Any other vulnerable subject at the time of enrollment as specified above
Who the study is looking for
- Adults 65-75 years of age at enrollment with at least one self-reported 1st-degree relative who had or has any kind of dementia
- Montreal Cognitive Assessment (MoCA) score \> 24 at initial enrollment
- Able and willing to comprehend and sign the informed consent document
- Able and willing to perform required physical performance tests
- Able and willing to provide the study's minimum samples
- Able and willing to conduct the study's minimum procedures
- Able and willing to complete surveys, cognitive assessments, and questionnaires in English only
- Has or has ready access to a PC, tablet, or smartphone with an internet connection required for procedures that they consent to
Age in the registry: 65 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Smith Family Clinic for Genomic Medicine Coordinator of this site? Confirm its status | Huntsville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.