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NCT07146503Recruiting

Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression

ESKPSY: Esketamine in Real-World Settings: Clinical Outcomes, Predictors of Response, Life Functioning and Biological Pathways

Source: ClinicalTrials.gov · Last updated 31 Mar 2026

Brief summary (registry, in English)

This observational study investigates the use of Esketamine Intranasal Spray in patients with Treatment-Resistant Depression in Real-World Settings. The study aims to evaluate the clinical outcomes, including efficacy and safety, of esketamine treatment. It also explores predictors of treatment response, focusing on biological pathways such as genetics, neuroimaging, and psychophysical measures. Additionally, the study examines how esketamine impacts patients' life functioning, including social and occupational aspects. The goal is to better understand who benefits most from esketamine and how it affects daily life, to improve personalized care for patients with difficult-to-treat depression.

Status (registry)
Recruiting
Study type
Observational
Enrollment
100 (estimated)
First submitted
20 Aug 2025
Start date
1 Nov 2022
Primary completion date
Jul 2026
Lead sponsor
Riccardo Guglielmo
Diseases
Depression
NCT number
NCT07146503

What you commit to

  • Study type: Observational
  • Planned participants: 100
  • From 1 Nov 2022 to the primary completion date, Jul 2026
  • 5 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Age in the registry: 18 years to 74 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (5)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Università di Chieti
Coordinator of this site? Confirm its status
ChietiItalyRecruiting
Ospedale Policlinico San Martino
Coordinator of this site? Confirm its status
GenovaItalyRecruiting
Csm Dds 8
Coordinator of this site? Confirm its status
GenovaItalyRecruiting
ASST Fatebenefratelli Sacco
Coordinator of this site? Confirm its status
MilanItalyRecruiting
ASST Pavia
Coordinator of this site? Confirm its status
PaviaItalyRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.