NCT07146906RecruitingPhase 2
A study to assess the effects of zigakibart on IgA nephropathy.
An open-label, uncontrolled, multicenter study to assess the effect of zigakibart treatment on histologic, circulating, and excreted markers of kidney disease and dysfunction in adult patients with IgA nephropathy
Source: EU CTIS (euclinicaltrials.eu) · Last updated 17 Aug 2026
Brief summary (registry, in English)
Does zigakibart treatment alter the course of disease in adults with IgAN?
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 5 Nov 2025
- Start date
- 23 Apr 2026
- Lead sponsor
- Novartis Pharma AG
- Diseases
- IgA nephropathy
- NCT number
- NCT07146906
- EU CT number
- 2024-519699-24-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 15
- 14 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has not used medications suppressing or affecting the immune system (not including short-term use of corticosteroids) in the past year.
Other illness
- Does not have urinary problems such as frequent urinary tract infections (UTIs) or trouble emptying the bladder.
Lab values
- Does not have a weakened immune system or unacceptably low immunoglobulin levels Total IgG (<6.0 g/L).
Other
- Does not have IgA vasculitis.
- Does not have high blood pressure that is not well controlled.
Who the study is looking for
- Male or female adults 18 years of age or older who weigh at least 45 kg with a BMI no greater than 35.0 kg/m2 and were diagnosed with IgAN within the past 5 years.
- Moderate kidney function (eGFR ≥45 mL/min/1.73 m²).
- Persistent protein in urine defined as total urine protein ≥0.5 g/day or urine protein-creatinine ratio (UPCR) ≥0.5 g/g despite supportive therapy, or total urine protein >1.5 g/day or UPCR >1.5 g/g at the time of clinical presentation or diagnosis if diagnosed within the past 6 months.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vseobecna fakultni nemocnice v Praze Coordinator of this site? Confirm its status | Prague | Czechia | Not yet recruiting |
| Medizinische Hochschule Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Recruiting |
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR Coordinator of this site? Confirm its status | Mainz | Germany | Recruiting |
| LMU Klinikum Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Recruiting |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Recruiting |
| University Hospital Virgen Del Rocio S.L. Coordinator of this site? Confirm its status | Sevilla | Spain | Recruiting |
| Hospital Universitario Dr. Peset Aleixandre Coordinator of this site? Confirm its status | Valencia | Spain | Recruiting |
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Coordinator of this site? Confirm its status | Brescia | Italy | Recruiting |
| Istituti Clinici Scientifici Maugeri S.p.A. Societa' Benefit In Forma Abbreviata Istituti Clinici Scientifici Maugeri S.p.A. Sb O Anche Ics Maugeri S.p.A. Sb O Maugeri S.p.A. Sb Coordinator of this site? Confirm its status | Pavia | Italy | Recruiting |
| Istituto Di Ricerche Farmacologiche Mario Negri Coordinator of this site? Confirm its status | Ranica | Italy | Recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Centralny Szpital Kliniczny Uniwersytetu Medycznego W Lodzi Coordinator of this site? Confirm its status | Lodz | Poland | Not yet recruiting |
| Uniwersytecki Szpital Kliniczny w Opolu Coordinator of this site? Confirm its status | Opole | Poland | Not yet recruiting |
| Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego Coordinator of this site? Confirm its status | Warsaw | Poland | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.