NCT07147179Recruiting
Short Course Radiotherapy
Pilot Trial of Short Course Radiotherapy for Primary or Secondary CNS Malignancies
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 27 Aug 2025
- Start date
- Apr 2026
- Primary completion date
- Mar 2027
- Lead sponsor
- Abramson Cancer Center at Penn Medicine
- Diseases
- Childhood cancers
- NCT number
- NCT07147179
What you commit to
- Study type: Interventional
- Planned participants: 15
- From Apr 2026 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Radiotherapy for curative intent
- Being planned for proton radiation
Other illness
- Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol
Who the study is looking for
- Male or female, aged 21 years or below
- Lansky performance status \>= 40
- Has a diagnosis of an incurable malignancy that:
- Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met
- Has at least 1 targetable intracranial lesion as seen on imaging
- Has a multidisciplinary consensus recommendation for palliative intent radiation
- Consents to the study or has caregiver who is able to provide signed and dated informed consent. For subjects under the age of 18, a signed and dated assent form as able.
- Patients who had prior radiation in planned treatment area are also eligible to enter the trial
- Stated willingness to comply with all study procedures and availability for the duration of the study
Age in the registry: - to 21 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.