NCT07147621Recruiting
Evaluation of Chemotherapy-induced Cognitive Disorders During the Treatment of Hematological Malignancies
Source: ClinicalTrials.gov · Last updated 6 Mar 2026
Brief summary (registry, in English)
Chemotherapy-induced cognitive disorders, such as memory problems, slowness of execution, inability to concentrate, and language difficulties, are sequelae that occur in patients undergoing chemotherapy or who have received chemotherapy. These symptoms lead to a degradation of the patients' quality of life and can have a significant social and familial impact. They are most commonly described in solid oncology, particularly in patients with breast cancer. Data about patients with hematological malignancies are scarce, but they seem to show the same phenomenon as in solid oncology. Indeed, many chemotherapies are used both in hematology and solid oncology and may therefore cause similar effects on cognition. Additionally, due to their mechanism of action, some chemotherapies specifically used in hematology could induce cognitive disorders. Hematology-treated patients are probably also affected by these disorders and may consequently experience a reduced quality of life. The objective of this study is to assess the changes in cognitive functions in patients receiving chemotherapy for the treatment of hematological malignancies, using neuropsychological tests and a self-administered questionnaire, compared to a control group, as well as their potential impact on quality of life, fatigue, anxiety, and depression.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 5 Aug 2025
- Start date
- 26 Feb 2026
- Primary completion date
- Oct 2026
- Lead sponsor
- University Hospital, Angers
- Diseases
- Acute myeloid leukemia
- NCT number
- NCT07147621
What you commit to
- Study type: Observational
- Planned participants: 120
- From 26 Feb 2026 to the primary completion date, Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient group exclusion criteria:
- no patient's relative for the control group;
- known or suspective cognitive disorders prior to chemotherapy;
- history of severe neurological or psychiatric disorders (e.g., severe depression); .previous chemotherapy;
- previous brain radiotherapy;
- ongoing treatments affecting cognition;
- patient unable to read;
- patient not speaking French;
- person deprived of liberty by judicial or administrative decision;
- person under forced psychiatric care;
- person under legal protection measures;
- person unable to express consent; .pregnant or breastfeeding woman.
- Control group exclusion criteria:
- known or suspected cognitive disorders;
- history of severe neurological or psychiatric disorder (e.g., severe depression); .previous chemotherapy;
- previous brain radiotherapy;
- ongoing treatments affecting cognition;
- person unable to read;
- person not speaking French;
- person deprived of liberty by judicial or administrative decision;
- person under forced psychiatric care;
- person under legal protection measures;
- person unable to express consent;
- pregnant or breastfeeding woman."
Who the study is looking for
- Patient group inclusion criteria:
- adult patient with acute myeloid leukemia, Hodgkin's lymphoma, or non-Hodgkin's lymphoma;
- patient receiving a fixed-duration first-line chemotherapy;
- patient affiliated or beneficiary of a social security scheme; .signed inform consent form.
- Control group inclusion criteria:
- adult;
- patient's relative (spouse, brother, sister, friend, etc.);
- less than 5 years of difference with the patient;
- same educational level (\< baccalaureate/high school degree, baccalaureate/high school degree level, 2-year university degree, \> 2-year university degree);
- person affiliated or beneficiary of a social security scheme;
- signed informed consent form
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University hospital of Angers Coordinator of this site? Confirm its status | Angers | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.