NCT07147751Not yet recruiting
Characterization of Primary Central Nervous System Diffuse Large B Cell Lymphoma (PCNS-DLBCL) by Multiomic Approach
Source: ClinicalTrials.gov · Last updated 22 Jun 2026
Brief summary (registry, in English)
PCNS-DLBCL is a rare extranodal non-Hodgkin lymphoma that primarily affects the brain, spine, or vitreoretinal space. The prognosis for PCNS-DLBCL is significantly worse than that for its systemic counterpart. Understanding how and where this tumor initiates, and how it survives or depends on the microenvironment of the CNS is key to understanding the underlying biology and identifying reliable biomarkers for selecting personalized therapy or for biologically directed therapy that could improve the cure rate of CNS lymphomas.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 22 Aug 2025
- Start date
- 1 Sept 2026
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- International Extranodal Lymphoma Study Group (IELSG)
- Diseases
- Diffuse large B-cell lymphoma
- NCT number
- NCT07147751
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Sept 2026 to the primary completion date, 31 Dec 2029
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Established immunodeficiency conditions.
Other
- Secondary CNS localizations of DLBCL
- Transformed DLBCL
Who the study is looking for
- Be an adult immunocompetent patient who received a PCNS-DLBCL diagnosis according to the WHO-HAEM5 criteria between 2018 and 2024.
- Availability of formalin-fixed paraffin-embedded (FFPE) diagnostic tumor material.
- Availability of the baseline and follow-up annotations
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oncology Institute of Southern Switzerland and Institute of Oncology Research Coordinator of this site? Confirm its status | Bellinzona | Switzerland | Unknown status |
| Fondazione IRCCS Policlinico San Matteo Pavia Coordinator of this site? Confirm its status | Pavia | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.