NCT07147842Completed
Rutin Therapy Role in Reducing Ulcerative Colitis Severity
Rutin Therapy Reduces Ulcerative Colitis Disease Activity By Inhibiting The NOD-Like Receptor Protein 3 (NLRP3) Inflammasome: A Molecular Assessment in a Case-Control Study
Source: ClinicalTrials.gov · Last updated 29 Aug 2025
Brief summary (registry, in English)
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by oxidative stress and recurring inflammation in the colon. The condition can become chronic, spread, and lead to other complications. A key player in the inflammation process is the NLRP3 inflammasome. This inflammasome's expression is heightened and activated by reactive oxygen species (ROS). Its activity is influenced by various factors, including the ubiquitin system, ion channels, and gut microbiota. Rutin, a compound found in many fruits and vegetables, has been shown to have properties that help scavenge free radicals.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 22 Aug 2025
- Start date
- 1 Nov 2024
- Primary completion date
- 8 Jan 2025
- Lead sponsor
- Benha University
- Diseases
- Ulcerative colitis
- NCT number
- NCT07147842
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 1 Nov 2024 to the primary completion date, 8 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with the presence of recurrent ulceration after surgical treatment, malignancy, or autoimmune disorders.
Who the study is looking for
- Patients presenting with symptoms suggestive of IBD;
- Patients with positive microscopic mucosal changes consistent with UC.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Benha University Coordinator of this site? Confirm its status | Banhā | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.