NCT07150169Not yet recruiting
Individualized Magnetic Stimulation for Post-stroke Cognitive Recovery: Optimization, Validation & Efficacy
Source: ClinicalTrials.gov · Last updated 2 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Rationale: 75% of all stroke survivors suffer from cognitive deficits in the acute phase, with serious implications for their long-term quality of life and societal participation. A promising novel therapy is repetitive transcranial magnetic stimulation (rTMS). Only a handful of studies have attempted to promote cognitive functioning after stroke with rTMS. These studies exclusively used a one-size-fits-all approach, which had limited success, as post-stroke cognitive deficits are highly variable. We propose a two-step personalized treatment strategy to identify targets for therapeutic TMS for cognitive rehabilitation after stroke. Step one consits of identification of personalized TMS targets by measuring fMRI activity during a representative cognitive task. In step two, TMS disruption is used to temporarily disrupt activity in the targeted brain region to investigate causal involvement of a brain area in cognitive task performance. Objective: To validate a proof-of-concept to identify personalized targets for therapeutic TMS for cognitive rehabilitation after stroke. Study design: A prospective mechanistic intervention study. Study population: 10 healthy individuals and 15 stroke patients with cognitive impairment Intervention: Active and sham TMS disruption of personalized targets Main study endpoints: The n-back test
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 25 (estimated)
- First submitted
- 24 Aug 2025
- Start date
- 1 Nov 2025
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- Jord Vink
- Diseases
- Stroke
- NCT number
- NCT07150169
What you commit to
- Study type: Interventional
- Planned participants: 25
- From 1 Nov 2025 to the primary completion date, 1 Oct 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Known cognitive impairment prior to stroke onset;
Other illness
- Absolute contra-indication to TMS: Magnetic sensitive objects implanted in the head or neck area (e.g. cochlear implants, implanted neurostimulator, pacemaker or defibrillator, metal splinters, metal fragments or metal clips), history of epilepsy, pregnancy or other contra-indications that may potentially be harmful as determined by the treating rehabilitation physician;
Other
- Incompetence or severe impairments that can impede study participation as determined by the treating rehabilitation physician (i.e. extreme fatigue, severe communication deficits);
- Life expectancy shorter than one year.
Who the study is looking for
- Age ≥ 18 years;
- First-ever ischemic stroke or intracerebral haemorrhage in a cerebral hemisphere or the brainstem;
- Cognitive impairment based on assessment by the treating rehabilitation physician.
- Able to perform n-back task at inclusion.
- Inclusion possible within 10 weeks after stroke onset;
- Signed informed consent.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.