NCT07151105Recruiting
Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity
Source: ClinicalTrials.gov · Last updated 1 Sept 2026
Brief summary (registry, in English)
This study is testing whether taking vitamin C every day can help improve gut health and reduce inflammation in adults with obesity. Poor gut health-sometimes called "leaky gut"-can allow harmful substances from bacteria to enter the bloodstream, which may lead to inflammation and increase the risk of heart disease and liver problems. Participants will complete two study periods, each lasting two weeks, with a two-week break in between. In one period, they will take vitamin C; in the other, a placebo. During each period, researchers will collect blood, urine, and stool samples, ask participants to track their diet and activity, and perform a test to measure gut permeability. There are minimal risks, such as discomfort from blood draws or temporary stomach upset from a sugar drink. While participants may not directly benefit, their involvement will help researchers learn whether vitamin C is a safe and effective way to improve gut health in people with obesity.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 34 (estimated)
- First submitted
- 27 Aug 2025
- Start date
- 1 Oct 2025
- Primary completion date
- 30 Dec 2027
- Lead sponsor
- Ohio State University
- Diseases
- Obesity
- NCT number
- NCT07151105
What you commit to
- Study type: Interventional
- Planned participants: 34
- From 1 Oct 2025 to the primary completion date, 30 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of anti-inflammatory drugs within past 1-month
- Use of certain medications that may interact with vitamin C, including blood thinners, some antiviral drugs (e.g., indinavir), and certain antipsychotic medications (e.g., fluphenazine).
Other illness
- Individuals with unmanaged or poorly controlled diabetes, dyslipidemia, hypertension
- Known history of bleeding disorders, hemochromatosis, or kidney stones
Other
- Current smoker or vaper, including tobacco, cannabis, or nicotine products
- Alcohol consumption \>2 drinks/day
- Use of antibiotics within past 1-month
- Use of probiotic supplements within past 1-month
- For Women: Pregnancy, lactation, or change in birth control within the past 3-months
Who the study is looking for
- English speaking
- Men and women between 18-50 years of age
- BMI 30-40 kg/m²
- Resting blood pressure \<140/90 mm Hg
- No use of multivitamin/vitamin C supplement within past 1-month
- Non-vegetarian/non-vegan
- Willingness to follow a diet low in fruits and vegetables for two, 2-week periods
Age in the registry: 18 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Ohio State University Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.