NCT07154394Recruiting
Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
Investigation of Cardiac Amyloid Deposits as a Cause of Cardiac Dysfunction in Alzheimer's Disease (Untersuchung Von Kardialen Amyloidablagerungen Als Ursache Einer Funktionseinschränkung Des Herzens Bei Alzheimer Demenz)
Source: ClinicalTrials.gov · Last updated 4 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart. The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia. This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 15 (estimated)
- First submitted
- 20 May 2025
- Start date
- 15 Aug 2022
- Primary completion date
- 14 Aug 2023
- Lead sponsor
- University Hospital, Essen
- Diseases
- Amyloidosis, Alzheimer disease
- NCT number
- NCT07154394
What you commit to
- Study type: Observational
- Planned participants: 15
- From 15 Aug 2022 to the primary completion date, 14 Aug 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol)
- Patients with pronounced cardiac preconditions
Other
- Pregnant and breastfeeding women
Who the study is looking for
- Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease
- No contraindications to undergo an MRI examination
- No contraindications to undergo an Amyloid PET scan
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Essen Coordinator of this site? Confirm its status | Essen | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.