NCT07155369Active, not recruiting
UCAR T-cell Therapy Targeting CD19/ BCMA in Patients With Relapse/ Refractory Autoimmune Diseases
A Clinical Study Evaluating the Safety and Efficacy of Universal Allogeneic CAR T-cell Therapy Targeting CD19 and BCMA in Patients With Relapse/Refractory Autoimmune Diseases
Source: ClinicalTrials.gov · Last updated 4 Sept 2025
Brief summary (registry, in English)
This is an investigator-initiated trial to evaluate the safety and efficacy of universal allogeneic anti-CD19/BCMA CAR T-cells in With Relapse/Refractory Autoimmune Diseases.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 18 (estimated)
- First submitted
- 20 Aug 2025
- Start date
- 18 Mar 2025
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- The Affiliated Hospital of Xuzhou Medical University
- NCT number
- NCT07155369
What you commit to
- Study type: Interventional
- Planned participants: 18
- From 18 Mar 2025 to the primary completion date, 30 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants with a history of severe drug allergies or allergic constitutions.
- Presence or suspicion of uncontrolled or treatment-required fungal, bacterial, viral, or other infections.
- Participants with insufficient cardiac function.
- History of malignancy within five years.
Other
- Participants with congenital immunoglobulin deficiencies.
Who the study is looking for
- Age ≥ 18 years old (inclusive), regardless of gender.
- Positive expression of CD19 on peripheral blood B cells confirmed by flow cytometry.
- Adequate hepatic, renal and bone marrow function.
- Participants with relapsed or refractory autoimmune diseases, Including SLE or SSc.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The affiliated hospital of xuzhou medical university Coordinator of this site? Confirm its status | Xuzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.