NCT07157527Not yet recruiting
Impact of Sacubitril/Valsartan on LV Diastolic Function in HFrEF
Impact of Sacubitril/Valsartan Therapy on Left Ventricular Diastolic Function in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF): An Echocardiographic Evaluation
Source: ClinicalTrials.gov · Last updated 5 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This prospective cohort study evaluates the effects of six months of sacubitril/valsartan (ARNI) therapy on left ventricular diastolic function in patients with heart failure with reduced ejection fraction (HFrEF) using transthoracic echocardiography. It aims to correlate echocardiographic parameters with clinical status and systolic function among Egyptian patients treated at two cardiology centers.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 70 (estimated)
- First submitted
- 28 Aug 2025
- Start date
- 1 Jun 2026
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Assiut University
- Diseases
- Heart failure
- NCT number
- NCT07157527
What you commit to
- Study type: Observational
- Planned participants: 70
- From 1 Jun 2026 to the primary completion date, 30 Sept 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with contraindication to ARNI therapy
- Patients with poor echocardiographic window
- Patients non-compliant with medication or follow-up
- Patients with mitral significant lesion or mitral prosthesis.
- Patients with atrial arrhythmia or on pacemaker
Who the study is looking for
- Diagnosed with HFrEF (LVEF \< 35%)
- Able to tolerate and comply with ARNI therapy
- Patients on Guideline-Directed Medical Therapy (GDMT) for heart failure
Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.