NCT07158125Not yet recruiting
Pathogenesis of Periodontal Disease in Individuals With Psoriasis
Role of Th17 and Stress-related Neuroendocrine Markers in the Pathogenesis of Periodontal Disease in Individuals With Psoriasis
Source: ClinicalTrials.gov · Last updated 5 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions. The fundamental question it aims to answer is: What are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis? In this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 28 Aug 2025
- Start date
- 15 Sept 2025
- Primary completion date
- 2 Feb 2026
- Lead sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Diseases
- Psoriasis
- NCT number
- NCT07158125
What you commit to
- Study type: Observational
- Planned participants: 60
- From 15 Sept 2025 to the primary completion date, 2 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Periodontal therapy and antibiotic therapy within the past 3 months
Other illness
- Any significant oral infection (i.e., herpes or candidiasis)
- Oral injuries or bleeding unrelated to periodontitis
- Acute illness (fever, sore throat)
- Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency
Other
- \<20 teeth
- Salivary gland dysfunction
- Pregnancy or breastfeeding
- Use of antidepressants
Who the study is looking for
- Being between the ages of 18 and 65
- Being diagnosed with psoriasis by a dermatologist
- Having at least 20 teeth
- Not having received periodontal treatment in the last 6 months
- Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
- Not having any autoimmune disease, osteoporosis, or cancer
- Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates
- Not being pregnant
- Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
- Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
- Not having taken antioxidant supplements in the last 6 months
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University Coordinator of this site? Confirm its status | Rize | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.