NCT07160218Completed
Effects of tDCS and Cognitive Rehabilitation on Cognition and Neural Plasticity in MS Patients
The Effect of Trans-cranial Direct Current Stimulation and Cognitive Rehabilitation on Cognitive Functions and Neuronal Plasticity inPatients With Multiple Sclerosis: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 8 Sept 2025
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate whether transcranial direct current stimulation (tDCS) and cognitive rehabilitation can improve cognitive functions and neuronal plasticity in patients with multiple sclerosis (MS). The participant population consists of MS patients (both sexes, adults), who commonly experience cognitive impairment in addition to physical and psychological symptoms. The main questions it aims to answer are: Does tDCS applied over the left dorsolateral prefrontal cortex improve cognitive abilities in MS patients? Does the combination of tDCS and cognitive rehabilitation enhance neuroplasticity, as measured by DTI, BDNF levels, and acetylcholinesterase activity?
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 45 (actual)
- First submitted
- 26 Aug 2025
- Start date
- Jan 2024
- Primary completion date
- Aug 2025
- Lead sponsor
- Shahid Beheshti University of Medical Sciences
- Diseases
- Multiple sclerosis
- NCT number
- NCT07160218
What you commit to
- Study type: Interventional
- Participants enrolled: 45
- From Jan 2024 to the primary completion date, Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of psychiatric disorders requiring treatment with neuroleptics.
- Recent MS relapse requiring steroid treatment.
Other illness
- History of seizures.
- History of brain surgery or presence of intracranial clips.
Other
- Left-handed individuals.
- Pregnant women.
Who the study is looking for
- Age between 20 and 50 years.
- Diagnosed with relapsing-remitting multiple sclerosis (RRMS).
- Mild disability, defined as EDSS \< 5.
- Patients who attended the neurology clinic and are willing to participate.
Age in the registry: 20 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shahid Beheshti University of Medical Science Coordinator of this site? Confirm its status | Tehran | Iran | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.