NCT07160868Recruiting
Obstructive Sleep Apnoea and Difficult Asthma (OSADA)
Open-label Randomized Controlled Trial Investigating the Relationship Between Obstructive Sleep Apnoea and Difficult Asthma
Source: ClinicalTrials.gov · Last updated 26 May 2026
Brief summary (registry, in English)
The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma. Participants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group). The primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, and quality of life compared to untreated OSA and to patients without OSA. Secondary outcomes include exacerbation rates, sleep quality, and healthcare utilization. This trial aims to clarify the contribution of OSA to poor asthma control and the potential benefits of integrated sleep and respiratory care in this complex population.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 24 Aug 2025
- Start date
- 1 Sept 2025
- Primary completion date
- 22 May 2026
- Lead sponsor
- St. James's Hospital, Ireland
- Diseases
- Asthma
- NCT number
- NCT07160868
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 1 Sept 2025 to the primary completion date, 22 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with previous sleep study investigations
- Previous diagnosis of a sleep disorder
- Resting hypoxaemia or need for long-term oxygen therapy
Other
- Excessive daytime sleepiness; ESS \>17
- Inability to provide informed consent
Who the study is looking for
- Patients must have a clinical diagnosis of asthma with supportive objective diagnostics including but not limited to, variable airflow obstruction, bronchial-hyper responsiveness and demonstrable eosinophilic inflammation via fractional exhaled nitric oxide or peripheral eosinophilia
- Patients receiving step 4 or step 5 of 'The Global Initiative for Asthma' (GINA) treatment guidelines will be selected
- Between the ages of 18 to 90 years of age
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. James's Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.