NCT07162467Enrolling by invitation
Tryptophan-Kynurenine Pathway Metabolism in the Pathophysiology of Cognitive Impairment in Schizophrenia.
Source: ClinicalTrials.gov · Last updated 14 Jan 2026
Brief summary (registry, in English)
Schizophrenia is a common, long-term mental illness. It causes problems with thoughts, feelings, and behavior, including positive symptoms (hallucinations, delusions), negative symptoms (lack of emotion, motivation), and cognitive impairment (trouble with thinking, memory, and attention). While antipsychotic drugs effectively treat positive symptoms, they don't help much with cognitive impairment.This study will examine how the tryptophan-kynurenine pathway in the brain contributes to cognitive problems in people having their first episode of schizophrenia and treated with a single antipsychotic. Our goal is to create models for early detection of cognitive impairment in schizophrenia and find potential targets for new treatments to improve thinking and memory.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 31 Aug 2025
- Start date
- 19 Feb 2024
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Tianjin Anding Hospital
- Diseases
- Schizophrenia
- NCT number
- NCT07162467
What you commit to
- Study type: Observational
- Planned participants: 200
- From 19 Feb 2024 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of psychoactive medications;
Other illness
- Significant comorbid medical or neurological conditions;
- Any DSM-5-defined psychiatric disorder;
- Family history of psychiatric illness spanning three or more generations;
Other
- Refusal to provide informed consent/participate.
Who the study is looking for
- Healthy volunteers matched to the patient group on sex, age, and education level;
- Ethnic Han Chinese;
- Able and willing to provide written informed consent.
Age in the registry: 18 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tianjin Anding Hospital Coordinator of this site? Confirm its status | Tianjin | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.