NCT07164742Recruiting
Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)
Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB PURE) A Randomized Multi-Centre Trial
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity. Randomization will occur in a 1:1:1 ratio at the initiation of treatment.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 690 (estimated)
- First submitted
- 2 Sept 2025
- Start date
- 18 Mar 2026
- Primary completion date
- 15 Sept 2028
- Lead sponsor
- Johns Hopkins University
- Diseases
- Tuberculosis
- NCT number
- NCT07164742
What you commit to
- Study type: Interventional
- Planned participants: 690
- From 18 Mar 2026 to the primary completion date, 15 Sept 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Bronchodilators and/or corticosteroids inhaled or otherwise.
Other illness
- Multi or extensively drug-resistant TB disease\*
- Extrapulmonary TB disease at any clinical sites without pulmonary involvement
- Symptomatic cardiovascular disease, including coronary artery disease, arrhythmias and congestive cardiac failure.
- Any medical condition that prevents pulmonary rehabilitation eg: fracture of lower/upper limbs/pregnancy
Other
- Modified Medical Research Council score of 0 points (dyspnea only with strenuous exercise)
- TB meningitis or TB of the spine
- Karnofsky Score \< 40 points
Who the study is looking for
- Age at least 18 years
- Microbiologically confirmed (smear microscopy, GeneXpert or culture) pulmonary TB disease\*
- Not completed more than 2 weeks of TB treatment
- Receiving TB care at the outpatient clinics at the TB PuRe study sites
- Willingness to complete 48 weeks of study evaluations.
- Access to a smartphone.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yenepoya (Deemed to be University Coordinator of this site? Confirm its status | Mangalore | India | Recruiting |
| Symbiosis Medical College for Women & Symbiosis University Hospital and Research Center Coordinator of this site? Confirm its status | Pune | India | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.