NCT07165678Recruiting
CTCA Prior to Invasive Angiography in Post-Bypass Patients (BYPASS CTCA 2)
A Multi-Centre, Randomised Trial Assessing the Value of Computed Tomography Coronary Angiography Prior to Invasive Coronary Angiography in Patients With Previous Coronary Artery Bypass Grafts in Reducing Cardiac Events
Source: ClinicalTrials.gov · Last updated 5 Jun 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate whether a coronary computed tomography angiography (CTCA)-guided strategy can reduce the risk of death, heart attack, stroke, and hospital admissions in patients experiencing angina or myocardial infarction following coronary artery bypass graft (CABG) surgery. The main questions it aims to answer are: * Can CTCA reduce major adverse cardiovascular events compared to standard invasive coronary angiography? * Is CTCA a cost-effective and safer alternative that improves patient quality of life? Researchers will compare outcomes between patients receiving CTCA prior to angiography and those undergoing standard angiography alone to determine if CTCA improves clinical outcomes and procedural safety. Participants will: * Be randomly assigned to either CTCA-guided care or standard angiography * Undergo coronary imaging and follow-up assessments * Complete questionnaires on quality of life and healthcare resource use
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1000 (estimated)
- First submitted
- 15 Aug 2025
- Start date
- 16 Apr 2026
- Primary completion date
- 31 Jul 2029
- Lead sponsor
- Queen Mary University of London
- Diseases
- Coronary artery disease
- NCT number
- NCT07165678
What you commit to
- Study type: Interventional
- Planned participants: 1000
- From 16 Apr 2026 to the primary completion date, 31 Jul 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subjects presenting with ST segment myocardial infarction within window for primary PCI
Lab values
- Patients considered unsuitable to participate by the research team (e.g. due to medical reasons, laboratory abnormalities, or subject's unwillingness to comply with all study related procedures)
Other
- Life expectancy less than 1 year
Who the study is looking for
- Aged ≥18
- Previous coronary artery bypass grafting (CABG)
- An indication for coronary angiography
- Angina
- Ischaemia on perfusion imaging
- Acute coronary syndrome
- Patients are able and willing to give their written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Bartholomew's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.