NCT07166874Recruiting
The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis
The Impacts of Gluten Free Diet on Disease Activity, Quality of Life and Intestinal Permeability in Patients Diagnosed With Ankylosing Spondylitis.
Source: ClinicalTrials.gov · Last updated 10 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development of the disease by increasing intestinal permeability. This study aims to determine the impacts of a gluten-freediet on intestinal permeability, sub-clinical intestinal inflammation, disease activity, functional status and quality of life in patients with ankylosing spondylitis. The main questions it aims to answer are: Does a gluten-free diet have an effect on disease activity and functional status in patients with ankylosing spondylitis? Does a gluten-free diet have an effect on intestinal permeability and subclinical intestinal inflammation in patients with ankylosing spondylitis? The investigators will evaluate the effects of the gluten-free diet compared to a control group.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 26 Aug 2025
- Start date
- 31 Jan 2025
- Primary completion date
- 30 Dec 2025
- Lead sponsor
- Saglik Bilimleri Universitesi
- Diseases
- Ankylosing spondylitis
- NCT number
- NCT07166874
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 31 Jan 2025 to the primary completion date, 30 Dec 2025
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any diet at the time of inclusion or within 3 months prior to inclusion;
Other illness
- have a history of celiac disease;
- have a history of Ulcerative Colitis, Crohn's Disease and Irritable Bowel Syndrom
- patients with Type 1 and Type 2 Diabetes Mellitus
Other
- patients with Hashimoto Thyroiditis
- are pregnant, breastfeeding,
- patients who have used omega-3 and vitamins (A, C, E) regularly in the last 3 months.
- BMI \<18,50 kg/m2
- BMI ≥29,99 kg/m2
Who the study is looking for
- diagnosis of axial SpA defined by ASAS criteria
- Adults (aged 18-64 years)
- stable treatment (NSAID and/or DMARD) for at least 3 months
- provide written informed consent and submit to the requirements of the study
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Marmara University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Active, not recruiting |
| Bakırköy Dr. Sadi Konuk Training and Research Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
| Istanbul Medeniyet University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Active, not recruiting |
| İstanbul Sağlık Bilimleri University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.