NCT07167147Completed
Survival Outcomes by Tumor-Node Stage and Recurrence Patterns in Colon Cancer After Radical Surgery
Source: ClinicalTrials.gov · Last updated 11 Sept 2025
Brief summary (registry, in English)
Colon cancer is one of the most common cancers worldwide, and even after curative (radical) surgery, some patients develop recurrence or distant metastasis. Understanding how tumor stage and lymph node status at the time of diagnosis influence the risk and patterns of recurrence is important for guiding follow-up and treatment strategies. This study retrospectively evaluates patients with stage I-III colon cancer who underwent radical surgery at Chang Gung Memorial Hospital between 2006 and 2018. A total of 7,259 patients are included from the institutional tumor registry. Patients are categorized into four tumor-node (TN) stage groups: * T1-3 without lymph node involvement * T1-3 with lymph node involvement * T4 without lymph node involvement * T4 with lymph node involvement The study aims to examine recurrence patterns (no recurrence, local recurrence, isolated lung metastasis, isolated liver metastasis, or multiple sites) and overall survival. Statistical analyses planned include Kaplan-Meier survival analysis and marginal structural models to compare outcomes across different TN stages and recurrence types. This study is based on retrospective data and was approved by the Institutional Review Board of Chang Gung Memorial Hospital (IRB No: 202500389B0). No new patient enrollment or interventions will be performed, and patient consent was waived due to the retrospective nature of the study.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 7259 (actual)
- First submitted
- 25 Aug 2025
- Start date
- 9 Apr 2025
- Primary completion date
- 30 Apr 2025
- Lead sponsor
- Chang Gung Memorial Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT07167147
What you commit to
- Study type: Observational
- Participants enrolled: 7259
- From 9 Apr 2025 to the primary completion date, 30 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who underwent only palliative surgery or local excision
Other illness
- Stage IV colon cancer at initial diagnosis
- History of other malignancies or synchronous multiple cancers
Other
- Non-adenocarcinoma histology (e.g., undifferentiated carcinoma, squamous cell carcinoma, lymphoma, sarcoma)
- Incomplete medical records or missing follow-up information
Who the study is looking for
- Patients with histologically confirmed colon adenocarcinoma
- Stage I-III disease at diagnosis
- Underwent curative (radical) resection at Chang Gung Memorial Hospital between 2006 and 2018
- Availability of complete clinical, pathological, and follow-up data
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chang Gung Memorial Hospital, Linkou Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.