NCT07167823Completed
The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront
Source: ClinicalTrials.gov · Last updated 15 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Empyema is a problem that thoracic surgeons deal in everyday practice. The main goal of treatment is evacuating the pus and fibrin deposits in the thoracic cavity for complete lung expansion. This study aims to report a detailed microbiological profile of patients operated for empyema thoracis and also correlate it with perioperative clinical outcomes. Patients who underwent surgery for empyema thoracis between January 2022 to June 2025 were included in the study. This study was carried out at two centers; Thoracic Surgery Department, Services Hospital Lahore. Patients were taken up for surgery after thorough preoperative evaluation. Perioperative outcomes were correlated with the results of microbiological analysis to evaluate their effect on clinical outcomes. This study highlights the emergence of Gram-negative organisms in bacterial empyema and emergence of multidrug resistance in tubercular empyema. Clinical outcome correlation revealed increased complications in culture-positive cases in both tubercular and nontubercular empyemas
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 350 (actual)
- First submitted
- 3 Sept 2025
- Start date
- 1 Jan 2022
- Primary completion date
- 30 Jun 2025
- Lead sponsor
- University of Health Sciences Lahore
- Diseases
- Tuberculosis
- NCT number
- NCT07167823
What you commit to
- Study type: Observational
- Participants enrolled: 350
- From 1 Jan 2022 to the primary completion date, 30 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Empyema cases resolved with medical management alone (antibiotics and/or chest tube drainage) without requiring surgical intervention.
Other illness
- Patients with non-infectious pleural effusions (e.g., malignant pleural effusion, hemothorax, or chylothorax).
- Patients with severe systemic conditions (e.g., end-stage organ failure, terminal malignancy) where empyema management was not the primary therapeutic focus.
Who the study is looking for
- Patients diagnosed with pleural empyema based on clinical, radiological, and microbiological confirmation.
- Patients who underwent surgical decortication for complicated or refractory empyema.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Services Institute of Medical Sciences (SIMS), Services Hospital Lahore Coordinator of this site? Confirm its status | Lahore | Pakistan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.