NCT07168447Not yet recruiting
Transfusion Exchanges and Cognition in Sickle Cell Disease
Effect of Exchange Transfusions on Cognitive Efficiency in Patients With Sickle Cell Disease
Source: ClinicalTrials.gov · Last updated 11 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0). Information processing speed is assessed at three time points during the transfusion cycle using the Symbol Digit Modalities Test (SDMT) and additional validated neuropsychological measures. This minimal-risk, fully remote study aims to identify processing speed as a reproducible marker for clinical monitoring and future therapeutic trials.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 85 (estimated)
- First submitted
- 18 Aug 2025
- Start date
- 3 Dec 2025
- Primary completion date
- 2 Nov 2027
- Lead sponsor
- Centre Hospitalier St Anne
- Diseases
- Sickle cell disease
- NCT number
- NCT07168447
What you commit to
- Study type: Observational
- Planned participants: 85
- From 3 Dec 2025 to the primary completion date, 2 Nov 2027
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known psychiatric disorders.
Other
- Insufficient mastery of spoken French.
- Severe comorbidities preventing short-term follow-up.
- Participation in another clinical study with ongoing exclusion periods.
- Lack of adequate computer equipment (minimum 11-inch screen and internet connection).
- Vulnerable patients under legal protection (guardianship or curatorship).
Who the study is looking for
- Adults (≥18 years) with severe sickle cell disease (SS or Sβ0).
- Enrolled in a regular monthly transfusion exchange program.
- Not institutionalized.
- No known dementia.
- No severe aphasia.
- Affiliated with or beneficiary of a social security system.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Assistance Publique Hôpitaux de Paris, Hôpital Avicenne Coordinator of this site? Confirm its status | Bobigny | France | Unknown status |
| Hopital Henri Mondor Coordinator of this site? Confirm its status | Créteil | France | Unknown status |
| Hôpital Kremlin-Bicêtre Coordinator of this site? Confirm its status | Le Kremlin-Bicêtre | France | Unknown status |
| GHU Paris Psychiatrie et Neurosciences - Hôpital Sainte-Anne Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Assistance Publique - Hôpitaux de Paris Hôpital Necker Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Centre Hospitalier Saint-Denis Coordinator of this site? Confirm its status | Saint-Denis | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.