NCT07173543Recruiting
IH, Brain Health, and T2D
Intermittent Hypoxia Training and Cerebrovascular Health in Older Adults With Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 13 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 2 Sept 2025
- Start date
- 22 Sept 2025
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- Darren P Casey
- Diseases
- Type 2 diabetes
- NCT number
- NCT07173543
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 22 Sept 2025 to the primary completion date, 30 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- diagnosis of type 2 diabetes \< 1 year prior to enrollment
Other illness
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- pulmonary disease
- dementia
- smoking or history of smoking within past one year
- 30 nondiabetic control subjects will also be studied.
- Diagnosis of diabetes (Type 1 or Type 2)
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- pulmonary disease
- dementia
- smoking or history of smoking within past one year
Lab values
- HbA1c \<6.5% or \>10.0%
- renal impairment with creatinine clearance (eGFR) of \<60 ml/min
- renal impairment with creatinine clearance (eGFR) of \<60 ml/min
Other
- body mass index \> 40 kg/m 2
- obstructive sleep apnea
- body mass index \> 40 kg/m2
- obstructive sleep apnea
Who the study is looking for
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Age is \> or = 60 and \< or = 85 years of age
- Documented Type 2 diabetes
- Scoring 26 or higher on the MoCA test
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Age is \> or = 60 and \< or = 85 years of age
- Scoring 26 or higher on the MoCA test
Criteria the registry did not label
- For 30 patients with documented Type 2 diabetes
Age in the registry: 60 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Iowa Coordinator of this site? Confirm its status | Iowa City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.