NCT07173855RecruitingPhase 4
Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
Effect of Protocolized Magnesium Replacement in Critically Ill Patients on Mortality and Atrial Fibrillation: the MAGNOLIA Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 24 Sept 2026
Brief summary (registry, in English)
In patients with critical illness, such as severe infections, heart attacks, or respiratory failure, most intensive care units (ICUs) measure magnesium levels and give supplemental doses of magnesium when levels are below certain targets. However, the best targets are unknown. The goal of this clinical trial is to study protocols for magnesium supplementation in people with critical illness, comparing a protocol with higher target level to a protocol with a lower target level. The main question this study aims to answer is whether magnesium supplementation protocols targeting a higher or lower level lead to better 30-day survival and less atrial fibrillation. Participants will not have to do any specific tasks, undergo any additional tests, or complete any surveys.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 3853 (estimated)
- First submitted
- 8 Sept 2025
- Start date
- 25 Nov 2025
- Primary completion date
- 1 Mar 2027
- Lead sponsor
- Scarborough General Hospital
- Diseases
- Atrial fibrillation
- NCT number
- NCT07173855
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 3853
- From 25 Nov 2025 to the primary completion date, 1 Mar 2027
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior enrollment in or withdrawal from MAGNOLIA trial
Other
- Sustained ventricular tachycardia
- Pre-eclampsia
- Myasthenia gravis
Who the study is looking for
- Age 16 years or older
- Admission orders written to a medical-surgical intensive care unit at a participating site
- Magnesium replacement protocol ordered
Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lakeridge Health Ajax-Pickering Coordinator of this site? Confirm its status | Ajax | Canada | Recruiting |
| Lakeridge Health Bowmanville Coordinator of this site? Confirm its status | Bowmanville | Canada | Recruiting |
| Lakeridge Health Oshawa Coordinator of this site? Confirm its status | Oshawa | Canada | Recruiting |
| Scarborough Birchmount Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Scarborough Centenary Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Scarborough General Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.