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NCT07173855RecruitingPhase 4

Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients

Effect of Protocolized Magnesium Replacement in Critically Ill Patients on Mortality and Atrial Fibrillation: the MAGNOLIA Randomized Controlled Trial

Source: ClinicalTrials.gov · Last updated 24 Sept 2026

Brief summary (registry, in English)

In patients with critical illness, such as severe infections, heart attacks, or respiratory failure, most intensive care units (ICUs) measure magnesium levels and give supplemental doses of magnesium when levels are below certain targets. However, the best targets are unknown. The goal of this clinical trial is to study protocols for magnesium supplementation in people with critical illness, comparing a protocol with higher target level to a protocol with a lower target level. The main question this study aims to answer is whether magnesium supplementation protocols targeting a higher or lower level lead to better 30-day survival and less atrial fibrillation. Participants will not have to do any specific tasks, undergo any additional tests, or complete any surveys.

Status (registry)
Recruiting
Phase (registry)
Phase 4
Study type
Interventional
Enrollment
3853 (estimated)
First submitted
8 Sept 2025
Start date
25 Nov 2025
Primary completion date
1 Mar 2027
Lead sponsor
Scarborough General Hospital
NCT number
NCT07173855

What you commit to

  • Study type: Interventional · Phase 4
  • Planned participants: 3853
  • From 25 Nov 2025 to the primary completion date, 1 Mar 2027
  • 6 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior enrollment in or withdrawal from MAGNOLIA trial

Other

  • Sustained ventricular tachycardia
  • Pre-eclampsia
  • Myasthenia gravis

Who the study is looking for

  • Age 16 years or older
  • Admission orders written to a medical-surgical intensive care unit at a participating site
  • Magnesium replacement protocol ordered

Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (6)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Lakeridge Health Ajax-Pickering
Coordinator of this site? Confirm its status
AjaxCanadaRecruiting
Lakeridge Health Bowmanville
Coordinator of this site? Confirm its status
BowmanvilleCanadaRecruiting
Lakeridge Health Oshawa
Coordinator of this site? Confirm its status
OshawaCanadaRecruiting
Scarborough Birchmount Hospital
Coordinator of this site? Confirm its status
TorontoCanadaRecruiting
Scarborough Centenary Hospital
Coordinator of this site? Confirm its status
TorontoCanadaRecruiting
Scarborough General Hospital
Coordinator of this site? Confirm its status
TorontoCanadaRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.