NCT07177963Not yet recruiting
CPET-based HIIT for MAFLD
Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving MAFLD
Source: ClinicalTrials.gov · Last updated 17 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
High-intensity interval training (HIIT), as an individualized exercise training mode based on cardiopulmonary exercise testing (CPET), is characterized by high-intensity training sessions interspersed with short rest periods. The findings from recent trials suggest that in the management of metabolic dysfunction-associated fatty liver disease (MAFLD), compared with traditional aerobic exercise modes such as moderate-intensity continuous training, HIIT may achieve similar or even better effects in reducing liver fat content, increasing peak oxygen uptake, improving insulin resistance, and lowering blood pressure, despite requiring less time commitment and lower energy expenditure. However, there is currently no consensus regarding the formulation of HIIT exercise protocols. Based on the lower limits of the current mainstream HIIT intensity, sets, and interval time parameters, this study aims to assess the effectiveness, safety, and feasibility of the current exercise prescription in improving MAFLD.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 54 (estimated)
- First submitted
- 3 Sept 2025
- Start date
- 8 Sept 2025
- Primary completion date
- 31 Mar 2026
- Lead sponsor
- Tang Yida
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT07177963
What you commit to
- Study type: Interventional
- Planned participants: 54
- From 8 Sept 2025 to the primary completion date, 31 Mar 2026
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving GLP-1 receptor agonists, SGLT-2i, or taking \>2 antihypertensive/hypoglycemic/lipid-lowering/ antiarrhythmic drugs
Other illness
- Mental illness
- Other liver diseases
- Movement disorder related diseases and lower limb motor injury in the past 6 months
Other
- Contraindications for Cardiopulmonary Exercise Testing
- The electrocardiogram (ECG) results during cardiopulmonary exercise testing (CPET) showed positive findings
- Taking dietary supplements (e.g., fish oil products, over-the-counter diet pills, meal replacements)
- Pregnant, lactating or planning to become pregnant in the near future
Who the study is looking for
- Adults age 35\~65 years Nonalcoholic fatty liver diagnosed by abdominal ultrasonography
- In conjunction with at least one cardiometabolic risk factor:
- Overweight or Obesity: ≥ 24kg/m2，or waist circumference ≥ 90 cm in men and \> 85 cm in women, or excessive body fat mass
- Prediabetes or type 2 diabetes mellitus: HbA1c ≥ 5.7%, or fasting plasma glucose ≥ 6.1mmol/L, or 2-h plasma glucose during OGTT ≥ 7.8mmol/L
- Plasma triglycerides ≥ 1.7 mmol/L (\>-150 mg/dl) or lipid-lowering treatment
- HDL-cholesterol ≤ -1.0 mmol/L in men and ≤ -1.3 mmol/L in women or lipid-lowering treatment
- Blood pressure ≥ 130/85 mmHg or treatment for hypertension
Age in the registry: 35 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing YouAn Hospital,Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Peking University Third Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Beijing Ditan Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Beijing Friendship Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| The Fifth Medical Center, Chinese PLA General Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.