NCT07181226Completed
High-Frequency vs. Theta-Burst TMS for Depression
High-Frequency vs. Theta-Burst TMS in Depression: Head-to-Head Double-Blind Randomized Trial With Six-week Follow-up
Source: ClinicalTrials.gov · Last updated 24 Sept 2025
Brief summary (registry, in English)
The goal of this clinical trial was to learn if two different types of repetitive transcranial magnetic stimulation (rTMS) could help treat depression and anxiety in adults with major depressive disorder. The main questions it aimed to answer were: Did high-frequency rTMS and intermittent theta-burst stimulation (iTBS) both reduce depressive symptoms? Did one treatment lead to greater improvement in anxiety symptoms? Researchers compared people receiving high-frequency rTMS to those receiving iTBS to see if one worked better for mood and anxiety symptoms. Participants: Were randomly assigned to one of the two treatment groups. Received 10 stimulation sessions over two weeks (five sessions per week). Completed questionnaires and interviews on depression, anxiety, and stress before treatment, after two weeks, and again six weeks later.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 108 (actual)
- First submitted
- 12 Sept 2025
- Start date
- 1 May 2022
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Krajská zdravotní, a.s. - Nemocnice Most, o.z.
- Diseases
- Depression
- NCT number
- NCT07181226
What you commit to
- Study type: Interventional
- Participants enrolled: 108
- From 1 May 2022 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of ferromagnetic or electronic implants in the head or neck (e.g., pacemakers, aneurysm clips, cochlear implants, deep brain stimulators).
- Ongoing electroconvulsive therapy (ECT) treatment.
- Medication changes made during the study.
Other illness
- Known seizure disorders (such as epilepsy) or significantly increased risk of seizures.
- Other major neurological diseases or conditions that would interfere with safe rTMS administration.
- Active psychotic symptoms or a primary psychotic disorder.
- Acute manic episode or recent hospitalization for mania or other severe psychiatric instability.
- Any medical or psychiatric condition judged by the investigators to compromise safety or data integrity.
Other
- Inability to comply with the treatment schedule (e.g., attendance problems, logistical barriers).
Who the study is looking for
- Adults aged 18 to 90 years.
- Current major depressive disorder (MDD) as the primary diagnosis, confirmed according to the International Classification of Diseases, 10th Revision (ICD-10).
- All participants had to be evaluated by a board-certified psychiatrist trained in rTMS to confirm eligibility.
- Ability and willingness to provide written informed consent prior to study participation.
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Krajská zdravotní, a.s. - Nemocnice Most, o.z. Coordinator of this site? Confirm its status | Most | Czechia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.