NCT07182955Recruiting
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
Determinants of Cardiorespiratory Fitness and Effects of High Intensity Interval Training (HIIT) in Patients With Angina and No Obstructive Coronary Artery Disease (ANOCA)
Source: ClinicalTrials.gov · Last updated 19 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life. Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 25 (estimated)
- First submitted
- 11 Jul 2025
- Start date
- 11 Aug 2025
- Primary completion date
- 30 Mar 2026
- Lead sponsor
- University of Virginia
- Diseases
- Coronary artery disease
- NCT number
- NCT07182955
What you commit to
- Study type: Interventional
- Planned participants: 25
- From 11 Aug 2025 to the primary completion date, 30 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior myocardial infarction, coronary revascularization
Lab values
- Systolic heart failure (LVEF \<50% or NYHA class III symptoms)
Other
- Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment
- Pregnancy (due to unknown effects on CPET exercise markers)
- Inability to provide informed consent
- Life expectancy \<1 year
- Prisoners
- Cognitively impaired
- Non-English speaking
Who the study is looking for
- Age 18-85
- ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
- Able to use the wearable and participate in a remote exercise program
- Able to participate in intermittent high-intensity training.
- Able to perform cardiopulmonary exercise testing (CPET)
- Able to provide Health-related quality of life questionnaire (HRQOL)
- Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Virginia Health System Coordinator of this site? Confirm its status | Charlottesville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.