NCT07183787CompletedPhase 2
Letrozole vs Danazol for Endometriosis-Related Pain: Randomized Trial
Comparison of Letrozole Versus Danazole for Pain Management of Female Presenting With Endometriosis
Source: ClinicalTrials.gov · Last updated 19 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Background: Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial glands and stroma outside the uterine cavity, most commonly diagnosed via laparoscopy. While its exact etiology remains uncertain, a positive family history is considered a significant risk factor. Danazol has historically demonstrated efficacy in alleviating endometriosis-related pain, while letrozole, primarily used in neoadjuvant settings, has recently emerged as a promising alternative. This study aimed to compare the mean reduction in pain scores between letrozole and danazol in women with laparoscopically confirmed endometriosis. Objective: To compare the efficacy of letrozole versus danazol in reducing pain scores among women diagnosed with endometriosis. Material \& Methods: Study Design: Randomized control trial Setting: Department of Obstetrics \& Gynaecology, Sharif Medical and Dental Hospital
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 14 Sept 2025
- Start date
- 10 Apr 2019
- Primary completion date
- 10 Oct 2019
- Lead sponsor
- Sidra Salman
- Diseases
- Endometriosis
- NCT number
- NCT07183787
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 60
- From 10 Apr 2019 to the primary completion date, 10 Oct 2019
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Pregnant or breastfeeding
- Severe hepatic disease, thromboembolic disorder, or contraindication to study drugs
- Use of hormonal therapy within the last 8 weeks
- Known hypersensitivity to Letrozole or Danazol
- Participation in another clinical trial within the last 3 months
Who the study is looking for
- Women aged 18-45 years
- Surgically or clinically diagnosed endometriosis
- Moderate to severe pelvic pain (NRS ≥ 4 for at least 3 months)
- Willing to use effective contraception during the study
- Able to provide informed consent
Age in the registry: 18 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sharif Medical and Dental College Coordinator of this site? Confirm its status | Lahore | Pakistan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.