NCT07185100Recruiting
Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
A Prospective, Cross-sectional, Nationwide Community-based Observational Study to Determine the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Source: ClinicalTrials.gov · Last updated 1 Apr 2026
Brief summary (registry, in English)
Heart failure (HF) in patients at risk is often overlooked, and when detected, there is a lack of early and effective preventive interventions. The WE-CARE-HF-CMR study, conducted in large cities/metropol areas in Germany ( \> 1.000.000 inhabitants), aims to close this gap by evaluating the feasibility of a mobile, telemedicinemonitored HF-screening approach combining cardiac magnetic resonance imaging (CMR), quality of life assessment and laboratory tests as key elements in asymptomatic patients at risk. WE-CARE-HF-CMR will provide a proposal for a comprehensive, contemporary screening approach for patients at risk to develop HF tailored to the needs of the target population. This will provide important new information on the prevalence of asymptomatic HF in at-risk patients in urban versus rural areas. The results of the study will be compared with the results from the "HERZCheck'' trial, which provides data from approximately 4,500 participants in rural areas in Germany and has already been completed (NCT05122793).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 600 (estimated)
- First submitted
- 10 Sept 2025
- Start date
- 13 Sept 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- German Heart Institute
- Diseases
- Heart failure
- NCT number
- NCT07185100
What you commit to
- Study type: Observational
- Planned participants: 600
- From 13 Sept 2025 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Haemodynamically unstable participants (heart rate \< 45/min, systolic blood pressure \< 90 mmHg)
- Acute mental disorders requiring therapy
Lab values
- Diagnosed heart failure or previously detected reduced ejection fraction
- Any MRI exclusion criteria not listed here, as determined by the MRI laboratory performing the procedure
Other
- Inability to provide written informed consent
- General MRI exclusion criteria (pacemaker, defibrillator, intracranial aneurysm clips, metallic foreign bodies in the eyes)
- Claustrophobia
- Sensorineural hearing loss of 30 dB or more and tinnitus
- In the presence of pregnancy
Who the study is looking for
- Asymptomatic subjects with:
- chronic diabetes mellitus (known/diagnosed and/or antidiabetic medication and/or elevated HbA1C) and/or
- renal impairment (known/diagnosed CKD and/or in laboratory CKD III° or higher) and/or
- Hypertension (known/diagnosed and/or antihypertensive medication/treatment) and/or
- Hypercholesterolaemia (known/diagnosed and/or antilipid medication/treatment) and/or
- Obesity (known/diagnosed and/or BMI \> 30 (kg/m²)) and/or
- Smoker (known/diagnosed and/or current/previous and/or medication/treatment)
- Age 40-69 years
- female or male or diverse sex
- Ability to provide informed consent
- Provision of Informed Consent
Age in the registry: 40 years to 69 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Deutsches Herzzentrum der Charité Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
Related publications
- Design and rationale of the WE-CARE-HF-CMR trial: Cardiorenal care on wheels for asymptomatic heart failure patients (NCT07185100).J Cardiovasc Magn Reson · 2026 · PMID 42142740
This page is information, not medical advice. Discuss any trial with your doctor.