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NCT07186296Recruiting

EXoPERT EMERALD Clinical Study

EXoPERT EMERALD: Early Multi-cancer Study of EV's Ramen-AL Linked Diagnosis Clinical Study Protocol

Source: ClinicalTrials.gov · Last updated 1 Jul 2026

Brief summary (registry, in English)

The purpose of this study is to establish a multi-center clinical repository of blood samples to support the development and evaluation of an artificial intelligence-based in vitro diagnostic software. The software analyzes surface-enhanced Raman spectroscopy (SERS) profiles of extracellular vesicles (EVs) extracted from human plasma for the early detection of multiple cancers, including lung, ovarian, breast, pancreatic, and colorectal cancers.

Status (registry)
Recruiting
Study type
Observational
Enrollment
1400 (estimated)
First submitted
29 Aug 2025
Start date
9 May 2025
Primary completion date
31 Aug 2026
Lead sponsor
EXoPERT
NCT number
NCT07186296

What you commit to

  • Study type: Observational
  • Planned participants: 1400
  • From 9 May 2025 to the primary completion date, 31 Aug 2026
  • 9 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Subjects who are currently in active treatment for drug abuse.
  • Subjects who have received any treatment related to lung, breast, colorectal, pancreatic, or ovarian nodules, such as hormones prior to entering the study.

Other illness

  • Any history of cancer diagnosed and treated within 5 years prior to the date of consent.
  • Subjects with a history of previous cancer treatment via surgical resection, hormonal cancer treatment, chemotherapy, radiotherapy within the past 6 months for recent cancer diagnosis.
  • Subjects who have any history of an allogeneic bone marrow, stem cell transplant, or solid organ transplant.
  • Subjects who have consented and have undergone treatment in any other cancer related clinical trials withinthe past 6 months.

Other

  • Subjects who are pregnant or breastfeeding women.
  • Unsuitable sample for testing due to contamination, hemolysis, etc.

Who the study is looking for

  • Subject aged 45 years or older with a biopsy-proven or clinically suspected primary lung, breast, colorectal, pancreatic, or ovarian cancer, based on objective findings such as radiological, serological, endoscopic, or cytological findings, whose blood was collected prior to any systemic or definitive therapy for the cancer.
  • Subjects who are willing and able to provide written informed consent.
  • Subjects who are willing and able to comply with the study requirements.

Age in the registry: 45 years to - · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (9)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Albany Stratton VA Medical Center
Coordinator of this site? Confirm its status
AlbanyUnited StatesRecruiting
John Hopkins University
Coordinator of this site? Confirm its status
BaltimoreUnited StatesRecruiting
University of Hawaii Cancer Center
Coordinator of this site? Confirm its status
HonoluluUnited StatesRecruiting
Lexington VA Healthcare System
Coordinator of this site? Confirm its status
LexingtonUnited StatesRecruiting
Tibor Rubin VA Medical Center
Coordinator of this site? Confirm its status
Long BeachUnited StatesRecruiting
City of Hope Duarte Cancer Center
Coordinator of this site? Confirm its status
Los AngelesUnited StatesRecruiting
KCTL
Coordinator of this site? Confirm its status
LouisvilleUnited StatesRecruiting
Bronx Veterans Medical Research Foundation
Coordinator of this site? Confirm its status
The BronxUnited StatesRecruiting
VA Hudson Valley Healthcare System
Coordinator of this site? Confirm its status
Wappingers FallsUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.