NCT07186296Recruiting
EXoPERT EMERALD Clinical Study
EXoPERT EMERALD: Early Multi-cancer Study of EV's Ramen-AL Linked Diagnosis Clinical Study Protocol
Source: ClinicalTrials.gov · Last updated 1 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to establish a multi-center clinical repository of blood samples to support the development and evaluation of an artificial intelligence-based in vitro diagnostic software. The software analyzes surface-enhanced Raman spectroscopy (SERS) profiles of extracellular vesicles (EVs) extracted from human plasma for the early detection of multiple cancers, including lung, ovarian, breast, pancreatic, and colorectal cancers.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1400 (estimated)
- First submitted
- 29 Aug 2025
- Start date
- 9 May 2025
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- EXoPERT
- NCT number
- NCT07186296
What you commit to
- Study type: Observational
- Planned participants: 1400
- From 9 May 2025 to the primary completion date, 31 Aug 2026
- 9 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Subjects who are currently in active treatment for drug abuse.
- Subjects who have received any treatment related to lung, breast, colorectal, pancreatic, or ovarian nodules, such as hormones prior to entering the study.
Other illness
- Any history of cancer diagnosed and treated within 5 years prior to the date of consent.
- Subjects with a history of previous cancer treatment via surgical resection, hormonal cancer treatment, chemotherapy, radiotherapy within the past 6 months for recent cancer diagnosis.
- Subjects who have any history of an allogeneic bone marrow, stem cell transplant, or solid organ transplant.
- Subjects who have consented and have undergone treatment in any other cancer related clinical trials withinthe past 6 months.
Other
- Subjects who are pregnant or breastfeeding women.
- Unsuitable sample for testing due to contamination, hemolysis, etc.
Who the study is looking for
- Subject aged 45 years or older with a biopsy-proven or clinically suspected primary lung, breast, colorectal, pancreatic, or ovarian cancer, based on objective findings such as radiological, serological, endoscopic, or cytological findings, whose blood was collected prior to any systemic or definitive therapy for the cancer.
- Subjects who are willing and able to provide written informed consent.
- Subjects who are willing and able to comply with the study requirements.
Age in the registry: 45 years to - · Sex: All · Accepts healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Albany Stratton VA Medical Center Coordinator of this site? Confirm its status | Albany | United States | Recruiting |
| John Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| University of Hawaii Cancer Center Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Lexington VA Healthcare System Coordinator of this site? Confirm its status | Lexington | United States | Recruiting |
| Tibor Rubin VA Medical Center Coordinator of this site? Confirm its status | Long Beach | United States | Recruiting |
| City of Hope Duarte Cancer Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| KCTL Coordinator of this site? Confirm its status | Louisville | United States | Recruiting |
| Bronx Veterans Medical Research Foundation Coordinator of this site? Confirm its status | The Bronx | United States | Recruiting |
| VA Hudson Valley Healthcare System Coordinator of this site? Confirm its status | Wappingers Falls | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.