Genetic Variants in Stroke

Prior treatment

• Inability to undergo magnetic resonance imaging (due to metal artifacts, MRI-incompatible implants, claustrophobia);
• Inability to undergo magnetic resonance imaging (due to metal artifacts, incompatible implants, claustrophobia);

Other illness

• Ischemic stroke with a distinct etiology based on TOAST criteria (e.g., infectious, autoimmune, endocarditis, reversible cerebral vasoconstriction syndrome, drug-related causes);
• Diagnosis of monogenic or mitochondrial disorders, such as CADASIL, Fabry disease, homocystinuria, MELAS, sickle cell disease, among others;
• Clinical conditions that reduce life expectancy to less than one year (e.g., neoplasia);
• Other conditions that, at the investigator's discretion, prevent participation or compromise follow-up.
  • Controls
• Personal history of stroke, transient ischemic attack (TIA), coronary, or peripheral artery disease;
• Clinical conditions that reduce life expectancy to less than one year;
• Inability to provide consent due to cognitive impairment or other factors;
• Diagnosis of monogenic or mitochondrial disorders, such as CADASIL, Fabry disease, homocystinuria, MELAS, or sickle cell disease;
• Other conditions that, at the investigator's discretion, prevent participation or compromise follow-up.

Other

• Cases
• Serious comorbidities that may impact participation or confound the results;

• Cases
• Age ≥18 years;
• Confirmed diagnosis by neuroimaging (CT or MRI) of a first episode of ischemic stroke in the last 12 months;
• TOAST classification of stroke available: cardioembolic, lacunar, atherosclerotic, or undetermined due to the presence of multiple sources (cardioembolic/atherosclerotic);
• Modified Rankin Scale (mRS) ≤4 at the time of inclusion;
• Ability and willingness to provide consent and participate in follow-up assessments.
  • Controls
• Age ≥18 years;
• Reside in the same household or, if not, in the same neighborhood as the case group participant;
• Not be a blood relative of the case group participant;
• Ability and willingness to provide consent and participate in follow-up assessments.