NCT07186959Enrolling by invitation
EGPSS for Weight Management in an in Vivo Human Model
A Novel Endoscopic Gastric Purse-string Suture Device for Weight Management in an in Vivo Human Model
Source: ClinicalTrials.gov · Last updated 22 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
ndoscopic bariatric and metabolic therapies (EBMTs) have introduced more convenient, minimally invasive, and safe approaches to weight management. Mucosal ablation of the gastric fundus has been reported to limit fundic expansion and promote satiety; however, ablation can cause perforation, infection, bleeding, and other complications. To restrain fundic expansion while minimizing surgical trauma and preserving reversibility, an endoscopic gastric purse-string suturing (EGPSS) technique was developed to reduce gastric volume. This procedure may be suitable for short-term weight management. Safety and feasibility were demonstrated in a porcine model. The present study will evaluate the feasibility of EGPSS in participants with obesity and assess histological and physiological outcomes.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 11 Sept 2025
- Start date
- 1 Jul 2024
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Liu Yan
- Diseases
- Obesity
- NCT number
- NCT07186959
What you commit to
- Study type: Interventional
- Planned participants: 15
- From 1 Jul 2024 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients who are suffering from severe organ failure requiring hospitalization;
- Patients allergic to anesthetics.
Other
- Women who are planning to conceive, pregnant, or breastfeeding;
- Patients who have undergone gastrectomy;
Who the study is looking for
- Patients with a body mass index (BMI) of 24-35 kg / m²;
- Patients accepted Lifestyle modifications, pharmacological interventions for weight loss which were unsuccessful or experienced a weight rebound;
- Patients willing to loss weight;
- Obese patients with metabolic disorders.
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Fifth medical center of Chinese PLA General Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.