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NCT07193680Recruiting

NOPE37: Angiogenic Factors for Managing Term Preeclampsia

Angiogenic Markers for Confirming Term Preeclampsia (noPE-37 Trial): An Open-Label, Randomized Controlled Trial

Source: ClinicalTrials.gov · Last updated 11 Dec 2025

Brief summary (registry, in English)

This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1/PlGF would reduce the rate of induction of labor without worsening the rate of progression to preeclampsia with severe features and other maternal complications.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
750 (estimated)
First submitted
21 Jul 2025
Start date
4 Dec 2025
Primary completion date
Dec 2027
Lead sponsor
Hospital Universitari Vall d'Hebron Research Institute
NCT number
NCT07193680

What you commit to

  • Study type: Interventional
  • Planned participants: 750
  • From 4 Dec 2025 to the primary completion date, Dec 2027
  • 23 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Preeclampsia with severe features according to the ACOG definition, eclampsia, or any condition that requires immediate delivery
  • Antiphospholipid antibody syndrome

Other

  • Fetal death
  • Absent or reversed end-diastolic flow in the umbilical artery Doppler
  • Non-reassuring CTG
  • Decreased fetal movements
  • Biophysical profile score ≤6
  • Oligohydramnios
  • Refusal to provide informed consent
  • Fetal malformation
  • Placental abruption

Who the study is looking for

  • Age ≥18 years
  • Singleton pregnancy
  • Preeclampsia without severe features according to the ACOG definition
  • Antegrade diastolic flow in the umbilical artery Doppler
  • Gestational age between 36+0 and 38+6 weeks of gestation
  • Gestational age confirmed by fetal crown-rump length measurement in the first-trimester scan (from 11+0 to 13+6 weeks of gestation) or by in vitro fertilization dates

Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (23)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Hospital Universitario de A Coruna
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A CoruñaSpainRecruiting
Hospital General Universitari Dr Balmis
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AlicanteSpainRecruiting
Vall d'Hebron Hospital Campus
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BarcelonaSpainRecruiting
Hospital Universitari Dexeus
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BarcelonaSpainRecruiting
Hospital Universitario de Cabueñes
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CabueñesSpainRecruiting
Hospital Universitario Puerta del Mar
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CadizSpainRecruiting
Hospital General Universitario de Elche
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ElcheSpainRecruiting
Hospital Universitario de Getafe
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GetafeSpainRecruiting
Hospital Universitari de Girona Doctor Josep Trueta
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GironaSpainRecruiting
Hospital Universitario San Cecilio
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GranadaSpainRecruiting
Hospital Universitario De Jerez
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Jerez de la FronteraSpainRecruiting
Hospital Materno Infantil de Gran Canaria
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Las Palmas de Gran CanariaSpainRecruiting
Hospital Universitari Arnau de Vilanova
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LleidaSpainRecruiting
Hospital Universitario 12 de Octubre
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MadridSpainRecruiting
Hospital Clínico Universitario Virgen de la Arrixaca
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MurciaSpainRecruiting
Hospital Universitari Son Espases
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Palma de MallorcaSpainRecruiting
Hospital Universitario Virgen de Valme
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SevilleSpainRecruiting
Hospital Universitario Virgen Macarena
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SevilleSpainRecruiting
Hospital Universitari de Tarragona Joan XXIII
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TarragonaSpainRecruiting
Hospital Universitari MutuaTerrassa
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TerrassaSpainRecruiting
Consorci Sanitari de Terrassa
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TerrassaSpainRecruiting
Hospital Universitario de Torrejon
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TorrejónSpainRecruiting
Hospital Universitario Lozano Blesa
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ZaragozaSpainRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.