NCT07193680Recruiting
NOPE37: Angiogenic Factors for Managing Term Preeclampsia
Angiogenic Markers for Confirming Term Preeclampsia (noPE-37 Trial): An Open-Label, Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 11 Dec 2025
Brief summary (registry, in English)
This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1/PlGF would reduce the rate of induction of labor without worsening the rate of progression to preeclampsia with severe features and other maternal complications.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 750 (estimated)
- First submitted
- 21 Jul 2025
- Start date
- 4 Dec 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- Hospital Universitari Vall d'Hebron Research Institute
- NCT number
- NCT07193680
What you commit to
- Study type: Interventional
- Planned participants: 750
- From 4 Dec 2025 to the primary completion date, Dec 2027
- 23 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Preeclampsia with severe features according to the ACOG definition, eclampsia, or any condition that requires immediate delivery
- Antiphospholipid antibody syndrome
Other
- Fetal death
- Absent or reversed end-diastolic flow in the umbilical artery Doppler
- Non-reassuring CTG
- Decreased fetal movements
- Biophysical profile score ≤6
- Oligohydramnios
- Refusal to provide informed consent
- Fetal malformation
- Placental abruption
Who the study is looking for
- Age ≥18 years
- Singleton pregnancy
- Preeclampsia without severe features according to the ACOG definition
- Antegrade diastolic flow in the umbilical artery Doppler
- Gestational age between 36+0 and 38+6 weeks of gestation
- Gestational age confirmed by fetal crown-rump length measurement in the first-trimester scan (from 11+0 to 13+6 weeks of gestation) or by in vitro fertilization dates
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (23)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario de A Coruna Coordinator of this site? Confirm its status | A Coruña | Spain | Recruiting |
| Hospital General Universitari Dr Balmis Coordinator of this site? Confirm its status | Alicante | Spain | Recruiting |
| Vall d'Hebron Hospital Campus Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Universitari Dexeus Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Universitario de Cabueñes Coordinator of this site? Confirm its status | Cabueñes | Spain | Recruiting |
| Hospital Universitario Puerta del Mar Coordinator of this site? Confirm its status | Cadiz | Spain | Recruiting |
| Hospital General Universitario de Elche Coordinator of this site? Confirm its status | Elche | Spain | Recruiting |
| Hospital Universitario de Getafe Coordinator of this site? Confirm its status | Getafe | Spain | Recruiting |
| Hospital Universitari de Girona Doctor Josep Trueta Coordinator of this site? Confirm its status | Girona | Spain | Recruiting |
| Hospital Universitario San Cecilio Coordinator of this site? Confirm its status | Granada | Spain | Recruiting |
| Hospital Universitario De Jerez Coordinator of this site? Confirm its status | Jerez de la Frontera | Spain | Recruiting |
| Hospital Materno Infantil de Gran Canaria Coordinator of this site? Confirm its status | Las Palmas de Gran Canaria | Spain | Recruiting |
| Hospital Universitari Arnau de Vilanova Coordinator of this site? Confirm its status | Lleida | Spain | Recruiting |
| Hospital Universitario 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Hospital Clínico Universitario Virgen de la Arrixaca Coordinator of this site? Confirm its status | Murcia | Spain | Recruiting |
| Hospital Universitari Son Espases Coordinator of this site? Confirm its status | Palma de Mallorca | Spain | Recruiting |
| Hospital Universitario Virgen de Valme Coordinator of this site? Confirm its status | Seville | Spain | Recruiting |
| Hospital Universitario Virgen Macarena Coordinator of this site? Confirm its status | Seville | Spain | Recruiting |
| Hospital Universitari de Tarragona Joan XXIII Coordinator of this site? Confirm its status | Tarragona | Spain | Recruiting |
| Hospital Universitari MutuaTerrassa Coordinator of this site? Confirm its status | Terrassa | Spain | Recruiting |
| Consorci Sanitari de Terrassa Coordinator of this site? Confirm its status | Terrassa | Spain | Recruiting |
| Hospital Universitario de Torrejon Coordinator of this site? Confirm its status | Torrejón | Spain | Recruiting |
| Hospital Universitario Lozano Blesa Coordinator of this site? Confirm its status | Zaragoza | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.