NCT07194954Completed
Dietary Fiber and Probiotics in Advanced Colorectal Cancer
Effects of Combined Dietary Fiber and Probiotic Supplementation on Gut Microbiota, Immune Function, and Clinical Outcomes in Patients With Advanced Colorectal Cancer: A Prospective Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 1 Oct 2025
Brief summary (registry, in English)
This single-center, prospective, randomized controlled trial was conducted to evaluate the efficacy of a 12-week combined dietary fiber and probiotic supplementation on gut microbiota, immune function, nutritional status, and survival outcomes in malnourished patients with advanced colorectal cancer undergoing conventional therapy, compared to standard nutritional support alone.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 80 (actual)
- First submitted
- 19 Sept 2025
- Start date
- 1 May 2022
- Primary completion date
- 1 Mar 2023
- Lead sponsor
- The First Hospital of Hebei Medical University
- Diseases
- Colorectal cancer
- NCT number
- NCT07194954
What you commit to
- Study type: Interventional
- Participants enrolled: 80
- From 1 May 2022 to the primary completion date, 1 Mar 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent participation in another interventional trial.
Other illness
- Severe, uncontrolled organ dysfunction (cardiac, hepatic, renal).
- Known allergy to any component of the nutritional supplements.
Other
- Presence of complete bowel obstruction.
Who the study is looking for
- Pathologically confirmed diagnosis of stage II-IV colorectal cancer post-resection.
- Receiving active adjuvant chemotherapy.
- Documented moderate-to-severe malnutrition (PG-SGA score ≥ 4).
- Ability to tolerate oral intake.
- Voluntarily signed the informed consent form.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| First Hospital of Hebei Medical University Coordinator of this site? Confirm its status | Shijiazhuang | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.